Properties and Functions of Myochondrocytes and Myochondroblasts in Different Human Cartilage Tissues-An Overview

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F25%3A00010187" target="_blank" >RIV/00023884:_____/25:00010187 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/25:10504258 RIV/00064203:_____/25:10504258 RIV/00064165:_____/25:10504258

Výsledek na webu

<a href="https://www.mdpi.com/2073-4409/14/19/1504" target="_blank" >https://www.mdpi.com/2073-4409/14/19/1504</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cells14191504" target="_blank" >10.3390/cells14191504</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Properties and Functions of Myochondrocytes and Myochondroblasts in Different Human Cartilage Tissues-An Overview

Popis výsledku v původním jazyce

A subset of chondrocytes in various human cartilage tissues, including neoplastic, regenerative, and normal cartilage, expresses alpha-smooth muscle actin (alpha-SMA), a protein typically found in smooth muscle cells. These alpha-SMA-containing chondrocytes, termed myochondrocytes and myochondroblasts, may play important roles in cartilage physiology, regeneration, and structural integrity, particularly in auricular and articular cartilage. This review synthesizes current knowledge regarding the terminology, distribution, and biological significance of these cells across normal, osteoarthritic, transplanted, and neoplastic cartilage. We summarize key findings from immunohistochemical studies using markers such as S-100, alpha-SMA, and SOX9, along with ultrastructural confirmation of myofilament bundles via electron microscopy. Current evidence suggests that myochondrocytes exhibit enhanced regenerative potential and contribute to matrix remodeling. Furthermore, their presence reflects the inherent cellular heterogeneity of cartilage, potentially arising from transdifferentiation processes involving fibroblasts, mesenchymal stem cells, or chondroblasts. Finally, TGF-beta 1 and PDGF-BB are identified as a critical modulator of alpha-SMA expression and chondrocyte phenotype. A deeper understanding of nature and function of myochondrocytes and myochondroblasts may improve interpretations of cartilage pathology and inform strategies for tissue engineering and cartilage repair. This review highlights the need for further investigation into the molecular regulation and functional roles of these cells in both physiological and pathological contexts.

Název v anglickém jazyce

Properties and Functions of Myochondrocytes and Myochondroblasts in Different Human Cartilage Tissues-An Overview

Popis výsledku anglicky

A subset of chondrocytes in various human cartilage tissues, including neoplastic, regenerative, and normal cartilage, expresses alpha-smooth muscle actin (alpha-SMA), a protein typically found in smooth muscle cells. These alpha-SMA-containing chondrocytes, termed myochondrocytes and myochondroblasts, may play important roles in cartilage physiology, regeneration, and structural integrity, particularly in auricular and articular cartilage. This review synthesizes current knowledge regarding the terminology, distribution, and biological significance of these cells across normal, osteoarthritic, transplanted, and neoplastic cartilage. We summarize key findings from immunohistochemical studies using markers such as S-100, alpha-SMA, and SOX9, along with ultrastructural confirmation of myofilament bundles via electron microscopy. Current evidence suggests that myochondrocytes exhibit enhanced regenerative potential and contribute to matrix remodeling. Furthermore, their presence reflects the inherent cellular heterogeneity of cartilage, potentially arising from transdifferentiation processes involving fibroblasts, mesenchymal stem cells, or chondroblasts. Finally, TGF-beta 1 and PDGF-BB are identified as a critical modulator of alpha-SMA expression and chondrocyte phenotype. A deeper understanding of nature and function of myochondrocytes and myochondroblasts may improve interpretations of cartilage pathology and inform strategies for tissue engineering and cartilage repair. This review highlights the need for further investigation into the molecular regulation and functional roles of these cells in both physiological and pathological contexts.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

<a href="/cs/project/LM2023033" target="_blank" >LM2023033: Síť českých biobank</a><br>

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cells

ISSN

2073-4409

e-ISSN

—

Svazek periodika

14

Číslo periodika v rámci svazku

19

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

13

Strana od-do

—

Kód UT WoS článku

001593509300001

EID výsledku v databázi Scopus

2-s2.0-105018648044