Differential allergen expression in three Tyrophagus putrescentiae strains inhabited by distinct microbiome

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027006%3A_____%2F19%3A00005551" target="_blank" >RIV/00027006:_____/19:00005551 - isvavai.cz</a>

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/abs/10.1111/all.13921?af=R" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1111/all.13921?af=R</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/all.13921" target="_blank" >10.1111/all.13921</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Differential allergen expression in three Tyrophagus putrescentiae strains inhabited by distinct microbiome

Popis výsledku v původním jazyce

The domestic mite, Tyrophagus putrescentiae, is a medically important, ubiquitous pest that commonly occurs in stored food and house dust, causing allergies. We analyzed the transcriptomes of three strains of T. putrescentiae, each harboring a different microbiome. These mite strains were analyzed at a level representative of a natural population using seven replicates. We found 78 transcripts belonging to 8 allergen groups known in T. putrescentiae (2, 3, 10, 13, 28, 34, 35 and 36) and identified 16 putative allergen groups previously unknown for this mite species (4, 5, 6, 7, 8, 11, 14, 16, 20, 24, 25, 27, 30, 31, 33 and 38). We documented polymorphism and differences in the expression level of these transcripts. Most importantly, the expression of several allergens (group 4, 7, 10, 11, 13, 20 and 36) was correlated with the presence of common intracellular bacterial symbionts, Wolbachia and Blattabacterium-like bacteria. The largest differences in allergen expression among the strains were found in allergen groups 2, 10, and 13 (known allergens) and groups 4 and 14 (putative allergens). We suggest that allergen production in T. putrescentiae may be affected by its microbiome composition.

Název v anglickém jazyce

Differential allergen expression in three Tyrophagus putrescentiae strains inhabited by distinct microbiome

Popis výsledku anglicky

The domestic mite, Tyrophagus putrescentiae, is a medically important, ubiquitous pest that commonly occurs in stored food and house dust, causing allergies. We analyzed the transcriptomes of three strains of T. putrescentiae, each harboring a different microbiome. These mite strains were analyzed at a level representative of a natural population using seven replicates. We found 78 transcripts belonging to 8 allergen groups known in T. putrescentiae (2, 3, 10, 13, 28, 34, 35 and 36) and identified 16 putative allergen groups previously unknown for this mite species (4, 5, 6, 7, 8, 11, 14, 16, 20, 24, 25, 27, 30, 31, 33 and 38). We documented polymorphism and differences in the expression level of these transcripts. Most importantly, the expression of several allergens (group 4, 7, 10, 11, 13, 20 and 36) was correlated with the presence of common intracellular bacterial symbionts, Wolbachia and Blattabacterium-like bacteria. The largest differences in allergen expression among the strains were found in allergen groups 2, 10, and 13 (known allergens) and groups 4 and 14 (putative allergens). We suggest that allergen production in T. putrescentiae may be affected by its microbiome composition.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10618 - Ecology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Allergy

ISSN

0105-4538

e-ISSN

—

Svazek periodika

74

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

2502-2507

Kód UT WoS článku

000517148400024

EID výsledku v databázi Scopus

2-s2.0-85067461038