Phenolics of Aerial Parts of Gentiana lutea L. and Their Biological Activity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027006%3A_____%2F21%3A10174307" target="_blank" >RIV/00027006:_____/21:10174307 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15640/21:73610862

Výsledek na webu

<a href="https://www.mdpi.com/2073-4395/11/7/1442/pdf" target="_blank" >https://www.mdpi.com/2073-4395/11/7/1442/pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/agronomy11071442" target="_blank" >10.3390/agronomy11071442</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Phenolics of Aerial Parts of Gentiana lutea L. and Their Biological Activity

Popis výsledku v původním jazyce

Gentiana lutea L. is a medicinal plant the roots of which are primarily used in treatments of various human digestive disorders, but also the production of alcoholic liquors. The roots (radix) of G. lutea are described in the European Pharmacopeia, but knowledge about the chemical composition and biological activities of its aerial parts is still limited. Thus, until today aerial parts of this species have not been used in medical treatments or consumed. Therefore, flowers, leaves, and stems extracts of G. lutea obtained by using four different extraction solvents (petrol ether, chloroform, ethanol, and water) were examined for their chemical composition and biological activities. High concentrations of salicylic acid, apigenin, and naringenin were recorded for ethanol stem extracts, while significant amounts of kaempferol were detected in leaves and flowers in chloroform and water extracts, respectively. The highest antioxidant potential was recorded for flower and stem petrol ether extracts with the lowest IC50 values, ranging from 94.46 +/- 9.45 to 105.38 +/- 10.54 mu g/mL. Ethanol extracts of flowers and stems showed moderate antioxidant activity (IC50 143.15 +/- 14.32 and 146.90 +/- 14.69 mu g/mL) as well as strong antimicrobial activity against Candida albicans (21.00 +/- 1.00 and 27.50 +/- 1.78 mm inhibition zones, respectively). In addition, ethanol extracts had higher antimycotic activity compared to naturally occurring phenolic compounds that are used as positive controls. Moreover, statistical analysis of the activities of plant extracts and single compounds showed that levels of chlorogenic and caffeic acids strongly correlate with the biological activities of the extracts, i.e., they are the main carriers of these biological activities. The presented results indicate the possible use of aerial parts of G. lutea as a natural preservative, as well as a antimicrobial agent, which significantly amplifies the benefits of this medicinal crop and greatly affects the sustainability of cultivated Gentiana plantation.

Název v anglickém jazyce

Phenolics of Aerial Parts of Gentiana lutea L. and Their Biological Activity

Popis výsledku anglicky

Gentiana lutea L. is a medicinal plant the roots of which are primarily used in treatments of various human digestive disorders, but also the production of alcoholic liquors. The roots (radix) of G. lutea are described in the European Pharmacopeia, but knowledge about the chemical composition and biological activities of its aerial parts is still limited. Thus, until today aerial parts of this species have not been used in medical treatments or consumed. Therefore, flowers, leaves, and stems extracts of G. lutea obtained by using four different extraction solvents (petrol ether, chloroform, ethanol, and water) were examined for their chemical composition and biological activities. High concentrations of salicylic acid, apigenin, and naringenin were recorded for ethanol stem extracts, while significant amounts of kaempferol were detected in leaves and flowers in chloroform and water extracts, respectively. The highest antioxidant potential was recorded for flower and stem petrol ether extracts with the lowest IC50 values, ranging from 94.46 +/- 9.45 to 105.38 +/- 10.54 mu g/mL. Ethanol extracts of flowers and stems showed moderate antioxidant activity (IC50 143.15 +/- 14.32 and 146.90 +/- 14.69 mu g/mL) as well as strong antimicrobial activity against Candida albicans (21.00 +/- 1.00 and 27.50 +/- 1.78 mm inhibition zones, respectively). In addition, ethanol extracts had higher antimycotic activity compared to naturally occurring phenolic compounds that are used as positive controls. Moreover, statistical analysis of the activities of plant extracts and single compounds showed that levels of chlorogenic and caffeic acids strongly correlate with the biological activities of the extracts, i.e., they are the main carriers of these biological activities. The presented results indicate the possible use of aerial parts of G. lutea as a natural preservative, as well as a antimicrobial agent, which significantly amplifies the benefits of this medicinal crop and greatly affects the sustainability of cultivated Gentiana plantation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40106 - Agronomy, plant breeding and plant protection; (Agricultural biotechnology to be 4.4)

Projekt

<a href="/cs/project/EF16_019%2F0000827" target="_blank" >EF16_019/0000827: Rostliny jako prostředek udržitelného globálního rozvoje</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Agronomy-Basel

ISSN

2073-4395

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

10

Strana od-do

1442

Kód UT WoS článku

000675927900001

EID výsledku v databázi Scopus

2-s2.0-85111401672