Genotoxic and cytotoxic assessment of two endemic Lamiaceae species from Bosnia and Herzegovina

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027006%3A_____%2F22%3A10175135" target="_blank" >RIV/00027006:_____/22:10175135 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15640/21:73607400

Výsledek na webu

<a href="https://www.tandfonline.com/toc/gnpl20/36/11" target="_blank" >https://www.tandfonline.com/toc/gnpl20/36/11</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/14786419.2021.1925275" target="_blank" >10.1080/14786419.2021.1925275</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Genotoxic and cytotoxic assessment of two endemic Lamiaceae species from Bosnia and Herzegovina

Popis výsledku v původním jazyce

Clinopodium alpinum subsp. orontium (K.Maly) Govaerts and Thymus bracteosus Vis. ex Benth. are endemic Lamiaceae species in Bosnia and Herzegovina with rather limited data about their cytotoxic and genotoxic effects. This study aimed to analyse phenolic compounds composition of C. alpinum subsp. orontium and T. bracteosus aqueous and dimethyl sulphoxide (DMSO) extracts and their cytotoxic and genotoxic potential in human peripheral blood lymphocyte cultures. Among 33 analytes, 17 were identified and quantified in the examined extracts with the rosmarinic and chlorogenic acids as main constituents. Genotoxic effects of extracts from both species are proven at the highest applied dose. T. bracteosus extracts and DMSO as a solvent exhibited stronger genotoxic potential that should be further investigated in tumour cell lines. Nevertheless, non-endemic species with similar phenolic composition and bioactivity should be the first choice for medicinal purposes.

Název v anglickém jazyce

Genotoxic and cytotoxic assessment of two endemic Lamiaceae species from Bosnia and Herzegovina

Popis výsledku anglicky

Clinopodium alpinum subsp. orontium (K.Maly) Govaerts and Thymus bracteosus Vis. ex Benth. are endemic Lamiaceae species in Bosnia and Herzegovina with rather limited data about their cytotoxic and genotoxic effects. This study aimed to analyse phenolic compounds composition of C. alpinum subsp. orontium and T. bracteosus aqueous and dimethyl sulphoxide (DMSO) extracts and their cytotoxic and genotoxic potential in human peripheral blood lymphocyte cultures. Among 33 analytes, 17 were identified and quantified in the examined extracts with the rosmarinic and chlorogenic acids as main constituents. Genotoxic effects of extracts from both species are proven at the highest applied dose. T. bracteosus extracts and DMSO as a solvent exhibited stronger genotoxic potential that should be further investigated in tumour cell lines. Nevertheless, non-endemic species with similar phenolic composition and bioactivity should be the first choice for medicinal purposes.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40106 - Agronomy, plant breeding and plant protection; (Agricultural biotechnology to be 4.4)

Projekt

<a href="/cs/project/LO1204" target="_blank" >LO1204: Udržitelný rozvoj výzkumu v Centru regionu Haná</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Natural Product Research

ISSN

1478-6419

e-ISSN

—

Svazek periodika

36

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

2888-2892

Kód UT WoS článku

000652791200001

EID výsledku v databázi Scopus

2-s2.0-85106246682