Exploring the Pharmacological Potential of Onosma riedliana: Phenolic Compounds and Their Biological Activities

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027006%3A_____%2F24%3A10177081" target="_blank" >RIV/00027006:_____/24:10177081 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15640/24:73624565

Výsledek na webu

<a href="https://link.springer.com/content/pdf/10.1007/s11130-023-01131-0.pdf" target="_blank" >https://link.springer.com/content/pdf/10.1007/s11130-023-01131-0.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11130-023-01131-0" target="_blank" >10.1007/s11130-023-01131-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Exploring the Pharmacological Potential of Onosma riedliana: Phenolic Compounds and Their Biological Activities

Popis výsledku v původním jazyce

Onosma riedliana Binzet &amp; Orcan, a traditionally used plant species, has been explored for its therapeutic potential in this study. The work presented here is the first report on the phenolic profile and biological activity of this species. Three extracts of varying polarity were prepared, with the methanolic extract containing the highest phenolic content (97.62 +/- 0.20 mgGAE/g). Key phenolic compounds identified included pinoresinol, hesperidin, 4-hydroxybenzoic acid, and p-coumaric acid. The methanolic extract exhibited exceptional antioxidant properties, rivaling Trolox as a positive control, primarily attributed to hesperidin and luteolin. Moreover, the ethyl acetate extract demonstrated remarkable inhibition of cholinesterase and tyrosinase enzymes, while the methanolic extract displayed potent activity against carbohydrate hydrolytic enzymes, alpha-amylase and alpha-glucosidase. Again, phenolic compounds were shown to be responsible for the inhibition of cholinesterases and tyrosinase, but not for alpha-amylase and alpha-glucosidase. These findings underscore Onosma riedliana&apos;s potential for incorporation into diverse pharmaceutical formulations, given its multifaceted bioactivity.

Název v anglickém jazyce

Exploring the Pharmacological Potential of Onosma riedliana: Phenolic Compounds and Their Biological Activities

Popis výsledku anglicky

Onosma riedliana Binzet &amp; Orcan, a traditionally used plant species, has been explored for its therapeutic potential in this study. The work presented here is the first report on the phenolic profile and biological activity of this species. Three extracts of varying polarity were prepared, with the methanolic extract containing the highest phenolic content (97.62 +/- 0.20 mgGAE/g). Key phenolic compounds identified included pinoresinol, hesperidin, 4-hydroxybenzoic acid, and p-coumaric acid. The methanolic extract exhibited exceptional antioxidant properties, rivaling Trolox as a positive control, primarily attributed to hesperidin and luteolin. Moreover, the ethyl acetate extract demonstrated remarkable inhibition of cholinesterase and tyrosinase enzymes, while the methanolic extract displayed potent activity against carbohydrate hydrolytic enzymes, alpha-amylase and alpha-glucosidase. Again, phenolic compounds were shown to be responsible for the inhibition of cholinesterases and tyrosinase, but not for alpha-amylase and alpha-glucosidase. These findings underscore Onosma riedliana&apos;s potential for incorporation into diverse pharmaceutical formulations, given its multifaceted bioactivity.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40106 - Agronomy, plant breeding and plant protection; (Agricultural biotechnology to be 4.4)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Plant Foods for Human Nutrition

ISSN

0921-9668

e-ISSN

1573-9104

Svazek periodika

79

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

106-112

Kód UT WoS článku

001126011600001

EID výsledku v databázi Scopus

2-s2.0-85179943798