Analysis of Genetic Diversity in the Czech Spotted Dog

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F20%3AN0000113" target="_blank" >RIV/00027014:_____/20:N0000113 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60460709:41210/20:81871

Výsledek na webu

<a href="https://www.mdpi.com/2076-2615/10/8/1416" target="_blank" >https://www.mdpi.com/2076-2615/10/8/1416</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ani10081416" target="_blank" >10.3390/ani10081416</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Analysis of Genetic Diversity in the Czech Spotted Dog

Popis výsledku v původním jazyce

Simple Summary Losses of genetic diversity have a particular impact on breed populations in countries with a small breeding base or national breeds with a small registry. Among them, it is possible to include the breed of the Czech Spotted Dog (CSD), whose variability has been low since the beginning of breeding due to the small number of founders and mating of close relatives. Through study of its pedigree records, we recorded a severe loss of genetic variability and high relatedness between animals. Moreover, the population is not free of genetic diseases; therefore, future existence of the breed is in danger. Loss off genetic diversity negatively affects most of the modern dog breeds. However, no breed created strictly for laboratory purposes has been analyzed so far. In this paper, we sought to explore by pedigree analysis exactly such a breed-the Czech Spotted Dog (CSD). The pedigree contained a total of 2010 individuals registered since the second half of the 20th century. Parameters such as the mean average relatedness, coefficient of inbreeding, effective population size, effective number of founders, ancestors and founder genomes and loss of genetic diversity-which was calculated based on the reference population and pedigree completeness-were used to assess genetic variability. Compared to the founding population, the reference population lost 38.2% of its genetic diversity, of which 26% is due to random genetic drift and 12.2% is due to the uneven contribution of the founders. The reference population is highly inbred and related. The average inbreeding coefficient is 36.45%, and the mean average relatedness is 74.83%. The effective population size calculated based on the increase of inbreeding coefficient is 10.28. Thus, the Czech Spotted Dog suffered significant losses of genetic diversity that threaten its future existence.

Název v anglickém jazyce

Analysis of Genetic Diversity in the Czech Spotted Dog

Popis výsledku anglicky

Simple Summary Losses of genetic diversity have a particular impact on breed populations in countries with a small breeding base or national breeds with a small registry. Among them, it is possible to include the breed of the Czech Spotted Dog (CSD), whose variability has been low since the beginning of breeding due to the small number of founders and mating of close relatives. Through study of its pedigree records, we recorded a severe loss of genetic variability and high relatedness between animals. Moreover, the population is not free of genetic diseases; therefore, future existence of the breed is in danger. Loss off genetic diversity negatively affects most of the modern dog breeds. However, no breed created strictly for laboratory purposes has been analyzed so far. In this paper, we sought to explore by pedigree analysis exactly such a breed-the Czech Spotted Dog (CSD). The pedigree contained a total of 2010 individuals registered since the second half of the 20th century. Parameters such as the mean average relatedness, coefficient of inbreeding, effective population size, effective number of founders, ancestors and founder genomes and loss of genetic diversity-which was calculated based on the reference population and pedigree completeness-were used to assess genetic variability. Compared to the founding population, the reference population lost 38.2% of its genetic diversity, of which 26% is due to random genetic drift and 12.2% is due to the uneven contribution of the founders. The reference population is highly inbred and related. The average inbreeding coefficient is 36.45%, and the mean average relatedness is 74.83%. The effective population size calculated based on the increase of inbreeding coefficient is 10.28. Thus, the Czech Spotted Dog suffered significant losses of genetic diversity that threaten its future existence.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40203 - Husbandry

Projekt

<a href="/cs/project/QK1910156" target="_blank" >QK1910156: Nové postupy pro záchranu ohrožených populací hospodářských zvířat</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Animals

ISSN

2076-2615

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

11

Strana od-do

Article Number: 1416

Kód UT WoS článku

000567257200001

EID výsledku v databázi Scopus

2-s2.0-85089696044