Haplotype disequilibrium in the TLR genes of Czech Red Pied cattle

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F23%3A10005815" target="_blank" >RIV/00027014:_____/23:10005815 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/23:10466824

Výsledek na webu

<a href="https://www.mdpi.com/1424-2818/15/7/811" target="_blank" >https://www.mdpi.com/1424-2818/15/7/811</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/d15070811" target="_blank" >10.3390/d15070811</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Haplotype disequilibrium in the TLR genes of Czech Red Pied cattle

Popis výsledku v původním jazyce

Hybrid resequencing using HiSeq and PacBio technologies of the antibacterial innate immune genes coding for toll-like receptors, namely TLR1, TLR2, TLR4, TLR5, and TLR6, in Czech Red Pied cattle (Czech Simmental) allowed us to determine haplotypes formed by the polymorphisms present. Directly determined haplotypes in the range of the large proximal amplicon in TLR2 formed two clusters in the network tree graph. Consistently, the distribution of the statistically reconstructed haplotypes was similar both in TLR2 and in other TLRs. Only the limited diversity of TLR1 did not allow for any assumption. The stability of this phenomenon cannot be ascribed to the historical origin but rather to a long-term effect of balancing selection. The equilibrium might be based on two different essential functions performed by the TLR genes or their products. The formation of two kinds of heterodimers by the TLR2 product, namely, TLR2/TLR1 and TLR2/TLR6 with different ligand specificities, is considered to be a particular case.

Název v anglickém jazyce

Haplotype disequilibrium in the TLR genes of Czech Red Pied cattle

Popis výsledku anglicky

Hybrid resequencing using HiSeq and PacBio technologies of the antibacterial innate immune genes coding for toll-like receptors, namely TLR1, TLR2, TLR4, TLR5, and TLR6, in Czech Red Pied cattle (Czech Simmental) allowed us to determine haplotypes formed by the polymorphisms present. Directly determined haplotypes in the range of the large proximal amplicon in TLR2 formed two clusters in the network tree graph. Consistently, the distribution of the statistically reconstructed haplotypes was similar both in TLR2 and in other TLRs. Only the limited diversity of TLR1 did not allow for any assumption. The stability of this phenomenon cannot be ascribed to the historical origin but rather to a long-term effect of balancing selection. The equilibrium might be based on two different essential functions performed by the TLR genes or their products. The formation of two kinds of heterodimers by the TLR2 product, namely, TLR2/TLR1 and TLR2/TLR6 with different ligand specificities, is considered to be a particular case.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40203 - Husbandry

Projekt

<a href="/cs/project/QJ1610489" target="_blank" >QJ1610489: Výskyt genetických faktorů pro infekční odolnost u vybraných plemen mléčného skotu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Diversity-Basel

ISSN

1424-2818

e-ISSN

—

Svazek periodika

15

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

15

Strana od-do

811

Kód UT WoS článku

001035280200001

EID výsledku v databázi Scopus

2-s2.0-85166205742