Tissue engineering scaffolds on the basis of composites of natural rubber.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027022%3A_____%2F23%3AN0000087" target="_blank" >RIV/00027022:_____/23:N0000087 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Tissue engineering scaffolds on the basis of composites of natural rubber.

Popis výsledku v původním jazyce

The aim of the study was development of tissue engineering constructs on the basis of composites of natural rubber. Natural rubber from the rubber tree Hevea brasiliensis belongs to natural biocompatible polymers and has been proved as inducing tissue repair by enhancing the vasculogenesis process, guiding and recruiting cells responsible for osteogenesis, and acting as a solid matrix for controlled drug release. The hyperelastic and viscoelastic properties predetermine the materials for many biomedical applications. It would be extremely useful if medical devices can be fabricated with materials that have these biological properties. Because of exceptionally high density of C atoms in polyisoprene molecule, NR and NRL have recently been center-stage because of the possibility to use Hevea brasiliensis and other polyisoprene latex producing plants for efficient carbon dioxide sequestration in accordance with the “Green Deal” initiative. Natural rubber has a potential to replace synthetic elastomers within certain scope, especially silicone. The toxic hexafluorosilicates used as foam stabilizers during industrial production of NRL foams has been replaced with safe foam stabilizers from the group of hyaluronate, agar-agar, natural polysaccharide gums, proteins (gelatine, collagens, albumins … ) , high molecular weight PVA polymers or others. The NRL foams with a hierarchical micro-macro porous interconnected hierarchical structure has been especially designed as scaffold for engineering of soft tissues. The microporous foams have been prepared by 1) modified Dunlop process using a planetary mixer or 2) pressure creaming with a nitrous oxide gas in a pressure vessel in combination with a new method of in-situ vulcanization using sodium thiosulfate and hydrochloric acid, inspired by Wang, et al., 2021, when sulphur is generated in situ by a chemical precipitation method. The prepared foam scaffolds were mineralised using standard procedures, characterised by standard physical-chemical methods and colonised and cultivated with proper tissue cells cultures, to verify their biocompatibility. Because of combination of super-elastic characteristics, thermal and chemical stability and biocompatibility, such materials seem to be especially suitable as fillers for plastic and aesthetic surgery. Biodegradability of the NR based composite biomaterials, generally very slow, can be modified in a wide range by suitable choice of additives, their concentrations and crosslinking methods.

Název v anglickém jazyce

Tissue engineering scaffolds on the basis of composites of natural rubber.

Popis výsledku anglicky

The aim of the study was development of tissue engineering constructs on the basis of composites of natural rubber. Natural rubber from the rubber tree Hevea brasiliensis belongs to natural biocompatible polymers and has been proved as inducing tissue repair by enhancing the vasculogenesis process, guiding and recruiting cells responsible for osteogenesis, and acting as a solid matrix for controlled drug release. The hyperelastic and viscoelastic properties predetermine the materials for many biomedical applications. It would be extremely useful if medical devices can be fabricated with materials that have these biological properties. Because of exceptionally high density of C atoms in polyisoprene molecule, NR and NRL have recently been center-stage because of the possibility to use Hevea brasiliensis and other polyisoprene latex producing plants for efficient carbon dioxide sequestration in accordance with the “Green Deal” initiative. Natural rubber has a potential to replace synthetic elastomers within certain scope, especially silicone. The toxic hexafluorosilicates used as foam stabilizers during industrial production of NRL foams has been replaced with safe foam stabilizers from the group of hyaluronate, agar-agar, natural polysaccharide gums, proteins (gelatine, collagens, albumins … ) , high molecular weight PVA polymers or others. The NRL foams with a hierarchical micro-macro porous interconnected hierarchical structure has been especially designed as scaffold for engineering of soft tissues. The microporous foams have been prepared by 1) modified Dunlop process using a planetary mixer or 2) pressure creaming with a nitrous oxide gas in a pressure vessel in combination with a new method of in-situ vulcanization using sodium thiosulfate and hydrochloric acid, inspired by Wang, et al., 2021, when sulphur is generated in situ by a chemical precipitation method. The prepared foam scaffolds were mineralised using standard procedures, characterised by standard physical-chemical methods and colonised and cultivated with proper tissue cells cultures, to verify their biocompatibility. Because of combination of super-elastic characteristics, thermal and chemical stability and biocompatibility, such materials seem to be especially suitable as fillers for plastic and aesthetic surgery. Biodegradability of the NR based composite biomaterials, generally very slow, can be modified in a wide range by suitable choice of additives, their concentrations and crosslinking methods.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30404 - Biomaterials (as related to medical implants, devices, sensors)

Projekt

<a href="/cs/project/NU20-08-00208" target="_blank" >NU20-08-00208: Nové vaskularizované konstrukty na bázi kmenových buněk pro inženýrství měkkých a tvrdých tkání</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů