Reaktivita křížově reagujících monoklonálních protilátek s leukocyty, trombocyty a erytrocyty psa

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F07%3A%230000169" target="_blank" >RIV/00027162:_____/07:#0000169 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Reactivity of cross-reacting monoclonal antibodies with canine leukocytes, platelets and erythrocytes

Popis výsledku v původním jazyce

A panel of 380 commercially available monoclonal antibodies (mAbs) against human CD molecules was tested for cross-reactivity on canine peripheral blood leukocytes, platelets and erythrocytes by flow cytometry. This testing resulted in 51 cross-reactingmAbs. mAbs with specificity for CD9, CD29, CD42a, CD61, and CD41/CD61 showed cross-reactivity with canine platelets and one mAb with the erythrocyte antigen CD235a. Canine leukocyte-reactive mAbs included those with specificity for CD11a, CD11b, CD14, CD18, CD21, CD22, CD47, CD49d, CD49e, CD56, CD62L, CD91, CD94, and CD172a. In addition, several mAbs resulted in a staining pattern of canine cells which suggest that the canine epitope equivalents have an alternate expression pattern from that expected for humans (CD1a, CD35, CD44, CD45, CD75s, CD81). In summary, this study confirmed the reactivity of previously described crossreactive mAbs with canine cells and resulted in the characterization of mAbs recognizing so far undetectable cani

Název v anglickém jazyce

Reactivity of cross-reacting monoclonal antibodies with canine leukocytes, platelets and erythrocytes

Popis výsledku anglicky

A panel of 380 commercially available monoclonal antibodies (mAbs) against human CD molecules was tested for cross-reactivity on canine peripheral blood leukocytes, platelets and erythrocytes by flow cytometry. This testing resulted in 51 cross-reactingmAbs. mAbs with specificity for CD9, CD29, CD42a, CD61, and CD41/CD61 showed cross-reactivity with canine platelets and one mAb with the erythrocyte antigen CD235a. Canine leukocyte-reactive mAbs included those with specificity for CD11a, CD11b, CD14, CD18, CD21, CD22, CD47, CD49d, CD49e, CD56, CD62L, CD91, CD94, and CD172a. In addition, several mAbs resulted in a staining pattern of canine cells which suggest that the canine epitope equivalents have an alternate expression pattern from that expected for humans (CD1a, CD35, CD44, CD45, CD75s, CD81). In summary, this study confirmed the reactivity of previously described crossreactive mAbs with canine cells and resulted in the characterization of mAbs recognizing so far undetectable cani

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

<a href="/cs/project/GP524%2F02%2FP010" target="_blank" >GP524/02/P010: Fenotypizace buněk imunitního systému psa</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinary Immunology and Immunopathology

ISSN

0165-2427

e-ISSN

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Svazek periodika

119

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

47-55

Kód UT WoS článku

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EID výsledku v databázi Scopus

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