Porovnání živých a inaktivovaných vakcín obsahující různé antigeny na ochranu drůbeže před Salmonella Typhimurium

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F08%3A%230000327" target="_blank" >RIV/00027162:_____/08:#0000327 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Comparison of live and inactivated Salmonella Typhimurium vaccines containing different combination of SPI-1 and SPI-2 antigens in poultry

Popis výsledku v původním jazyce

Salmonella enterica subsp. enterica originating from poultry is responsible for vast majority of human gastrointestinal disorders in Europe. This is why different measures how to decrease its incidence in poultry including vaccination are still being tested. In this study we compared 4 different inactivated vaccines of S. Typhimurium in chicken which were enriched by SPI-1 or SPI-2 proteins that are central to Salmonella virulence. Six-week-old chicken were intramuscularly vaccinated, revaccinated at 9weeks and challenged at 12 weeks of age. For 2 weeks post challenge the feacal shedding was monitored. There was no significant difference in performance of the 4 compared inactivated vaccines and all of them decreased faecal shedding during the first weeks post infection by 10-1000x when compared with non-immunized control chickens. However the level of protection induced by inactivated vaccines was much lower when compared with the live vaccine based on phoP rpoS double deletion S. Typ

Název v anglickém jazyce

Comparison of live and inactivated Salmonella Typhimurium vaccines containing different combination of SPI-1 and SPI-2 antigens in poultry

Popis výsledku anglicky

Salmonella enterica subsp. enterica originating from poultry is responsible for vast majority of human gastrointestinal disorders in Europe. This is why different measures how to decrease its incidence in poultry including vaccination are still being tested. In this study we compared 4 different inactivated vaccines of S. Typhimurium in chicken which were enriched by SPI-1 or SPI-2 proteins that are central to Salmonella virulence. Six-week-old chicken were intramuscularly vaccinated, revaccinated at 9weeks and challenged at 12 weeks of age. For 2 weeks post challenge the feacal shedding was monitored. There was no significant difference in performance of the 4 compared inactivated vaccines and all of them decreased faecal shedding during the first weeks post infection by 10-1000x when compared with non-immunized control chickens. However the level of protection induced by inactivated vaccines was much lower when compared with the live vaccine based on phoP rpoS double deletion S. Typ

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

<a href="/cs/project/LC06030" target="_blank" >LC06030: Biomolekulární centrum</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinární medicína

ISSN

0375-8427

e-ISSN

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Svazek periodika

53

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

9

Strana od-do

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Kód UT WoS článku

000257542700003

EID výsledku v databázi Scopus

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