Estrogenní aktivita polycyklických aromatických uhlovodíků v děloze immaturních Wistar potkanů

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F08%3A%230000359" target="_blank" >RIV/00027162:_____/08:#0000359 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081707:_____/08:00311096

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Estrogenic activity of environmental polycyclic aromatic hydrocarbons in uterus of immature Wistar rats

Popis výsledku v původním jazyce

The study: estrogenic/antiestrogenic effects of benzo(a)pyrene (BaP), benz(a)anthracene (BaA), fluoranthene (Fla) and benzo(k)fluoranthene (BkF), using the immature rat uterotrophic assay. The results suggest that BaA, BaP and Fla behaved as estrogen-like compounds, when applied at 10 mg/kg/day, as documented by a significant increase of uterine weight and hypertrophy of luminal epithelium. These effects were likely to be mediated by ER alpha, which was downregulated following the treatment with PAHs, as they were inhibited by treatment with ER antagonist ICI 182,780. BaA induced a significant estrogenic effect already at the dose of 0.1 mg/kg/day. The proposed antiestrogenicity of the potent AhR agonist BkF was not confirmed. The PAHs under study didnot induce marked genotoxic damage in uterine tissues, as documented by the lack of Ser-15-phoshorylated p53 protein staining. With the exception of Fla, all three remaining PAHs increased CYP1-dependent monooxygenation activities in live

Název v anglickém jazyce

Estrogenic activity of environmental polycyclic aromatic hydrocarbons in uterus of immature Wistar rats

Popis výsledku anglicky

The study: estrogenic/antiestrogenic effects of benzo(a)pyrene (BaP), benz(a)anthracene (BaA), fluoranthene (Fla) and benzo(k)fluoranthene (BkF), using the immature rat uterotrophic assay. The results suggest that BaA, BaP and Fla behaved as estrogen-like compounds, when applied at 10 mg/kg/day, as documented by a significant increase of uterine weight and hypertrophy of luminal epithelium. These effects were likely to be mediated by ER alpha, which was downregulated following the treatment with PAHs, as they were inhibited by treatment with ER antagonist ICI 182,780. BaA induced a significant estrogenic effect already at the dose of 0.1 mg/kg/day. The proposed antiestrogenicity of the potent AhR agonist BkF was not confirmed. The PAHs under study didnot induce marked genotoxic damage in uterine tissues, as documented by the lack of Ser-15-phoshorylated p53 protein staining. With the exception of Fla, all three remaining PAHs increased CYP1-dependent monooxygenation activities in live

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

<a href="/cs/project/GA525%2F05%2F2695" target="_blank" >GA525/05/2695: Účinky neonatální expozice polycyklickým aromatickým uhlovodíkům na reprodukční a imunitní systém</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Toxicology Letters

ISSN

0378-4274

e-ISSN

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Svazek periodika

180

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

10

Strana od-do

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Kód UT WoS článku

000259461000008

EID výsledku v databázi Scopus

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