Morphological and functional disorders of the immature rat uterus after postnatal exposure to benz(a)anthracene and benzo(k)fluoranthene

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F09%3A%230000486" target="_blank" >RIV/00027162:_____/09:#0000486 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Morphological and functional disorders of the immature rat uterus after postnatal exposure to benz(a)anthracene and benzo(k)fluoranthene

Popis výsledku v původním jazyce

The objective of this study was to investigate the effects of postnatal exposure to benz(a)anthracene (B(a)A) and benzo(k)fluoranthene (B(k)F) on the development of the rat uterus. Neonates were injected subcutaneously on each postnatal day 1-14 with B(a)A (0.1, 1.0 or 10.0 mg/kg), B(k)F (0.1, 1.0 or 5.0 mg/kg), ethynylestradiol (EE; 1.0 ug/kg) or a vehicle. The rats were killed on day 23. All doses of B(a)A and B(k)F induced a significant reduction of the uterine weight, a reduction of the estrogen receptor alpha expression in the luminal epithelium, glandular epithelium and stromal cells. Moreover, the uterotrophic response to EE (three-day administration of 1.0 ug/kg on postnatal days 20-22) in rats exposed to B(a)A, B(k)F and EE was significantly lower than in controls. The study showed that postnatal exposure to B(a)A or B(k)F results in morphological and functional disorders of the immature rat uterus.

Název v anglickém jazyce

Morphological and functional disorders of the immature rat uterus after postnatal exposure to benz(a)anthracene and benzo(k)fluoranthene

Popis výsledku anglicky

The objective of this study was to investigate the effects of postnatal exposure to benz(a)anthracene (B(a)A) and benzo(k)fluoranthene (B(k)F) on the development of the rat uterus. Neonates were injected subcutaneously on each postnatal day 1-14 with B(a)A (0.1, 1.0 or 10.0 mg/kg), B(k)F (0.1, 1.0 or 5.0 mg/kg), ethynylestradiol (EE; 1.0 ug/kg) or a vehicle. The rats were killed on day 23. All doses of B(a)A and B(k)F induced a significant reduction of the uterine weight, a reduction of the estrogen receptor alpha expression in the luminal epithelium, glandular epithelium and stromal cells. Moreover, the uterotrophic response to EE (three-day administration of 1.0 ug/kg on postnatal days 20-22) in rats exposed to B(a)A, B(k)F and EE was significantly lower than in controls. The study showed that postnatal exposure to B(a)A or B(k)F results in morphological and functional disorders of the immature rat uterus.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

<a href="/cs/project/GA525%2F05%2F2695" target="_blank" >GA525/05/2695: Účinky neonatální expozice polycyklickým aromatickým uhlovodíkům na reprodukční a imunitní systém</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Toxicology and Pharmacology

ISSN

1382-6689

e-ISSN

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Svazek periodika

27

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

000264387200014

EID výsledku v databázi Scopus

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