Sperm chromatin integrity in young men with no experiences of infertility and men from idiopathic infertility couples

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F09%3A%230000506" target="_blank" >RIV/00027162:_____/09:#0000506 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Sperm chromatin integrity in young men with no experiences of infertility and men from idiopathic infertility couples

Popis výsledku v původním jazyce

Damage to the genetic component of sperm seems to play the main role in the majority of cases where current approaches fail to reveal the specific cause of male infertility. In the present study, we compared semen quality in men assigned to two defined groups: men from couples with unexplained infertility - idiopathic infertility (A) and young men with no experiences of infertility (B). All samples were examined by standard ejaculate analysis and Sperm chromatin Structure Assay (SCSA). Sperm chromatin damage was significantly higher in men from group A in comparison with men from group B. Similar results were obtained by comparison of men from group A (all men were normozoospermic) and normozoospermic men from groups B. According to these results, we can suppose that chromatin disorders may be the causal factor of subfertility or infertility in some of these men. SCSA is a method which facilitates the identification of infertile men who otherwise show normal semen variables.

Název v anglickém jazyce

Sperm chromatin integrity in young men with no experiences of infertility and men from idiopathic infertility couples

Popis výsledku anglicky

Damage to the genetic component of sperm seems to play the main role in the majority of cases where current approaches fail to reveal the specific cause of male infertility. In the present study, we compared semen quality in men assigned to two defined groups: men from couples with unexplained infertility - idiopathic infertility (A) and young men with no experiences of infertility (B). All samples were examined by standard ejaculate analysis and Sperm chromatin Structure Assay (SCSA). Sperm chromatin damage was significantly higher in men from group A in comparison with men from group B. Similar results were obtained by comparison of men from group A (all men were normozoospermic) and normozoospermic men from groups B. According to these results, we can suppose that chromatin disorders may be the causal factor of subfertility or infertility in some of these men. SCSA is a method which facilitates the identification of infertile men who otherwise show normal semen variables.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/1QS500390506" target="_blank" >1QS500390506: Vliv environmentálních a genetických faktorů na fertilitu mužů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Andrologia

ISSN

0303-4569

e-ISSN

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Svazek periodika

41

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

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Kód UT WoS článku

000265480700002

EID výsledku v databázi Scopus

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