Deletion of sodCI and spvBC in Salmonella e enterica serovar Enteritidis reduced its virulence to the natural virulence of serovar Agona, Hadar and Infantis for mice but not for chickens early after infection

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F09%3A%230000510" target="_blank" >RIV/00027162:_____/09:#0000510 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Deletion of sodCI and spvBC in Salmonella e enterica serovar Enteritidis reduced its virulence to the natural virulence of serovar Agona, Hadar and Infantis for mice but not for chickens early after infection

Popis výsledku v původním jazyce

Salmonella enterica serovars Typhimurium or Enteritidis can colonise liver and spleen in particular hosts while infections with serovars Infantis, Agona, Hadar etc. are usually limited to gastrointestinal tract. Reasons for this behavior are unknown, although it has been shown that sodCI and spv genes exhibit a strict distribution between more and less virulent serovars and they influence Salmonella virulence. In this study we therefore removed these two genes from S. Enteritidis genome and compared thevirulence of such a mutant with the virulence of S. Infantis, S. Agona and S. Hadar for chickens and highly sensitive Balb/C mice. Single strain infections showed that the deletion of these two genes from S. Enteritidis resulted in the reduction of itsvirulence for mice but not for chickens. This indicated that in mice but not in chickens the virulence of sodCI and spv mutant was reduced to the natural virulence of serovars Infantis, Agona and Hadar.

Název v anglickém jazyce

Deletion of sodCI and spvBC in Salmonella e enterica serovar Enteritidis reduced its virulence to the natural virulence of serovar Agona, Hadar and Infantis for mice but not for chickens early after infection

Popis výsledku anglicky

Salmonella enterica serovars Typhimurium or Enteritidis can colonise liver and spleen in particular hosts while infections with serovars Infantis, Agona, Hadar etc. are usually limited to gastrointestinal tract. Reasons for this behavior are unknown, although it has been shown that sodCI and spv genes exhibit a strict distribution between more and less virulent serovars and they influence Salmonella virulence. In this study we therefore removed these two genes from S. Enteritidis genome and compared thevirulence of such a mutant with the virulence of S. Infantis, S. Agona and S. Hadar for chickens and highly sensitive Balb/C mice. Single strain infections showed that the deletion of these two genes from S. Enteritidis resulted in the reduction of itsvirulence for mice but not for chickens. This indicated that in mice but not in chickens the virulence of sodCI and spv mutant was reduced to the natural virulence of serovars Infantis, Agona and Hadar.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

<a href="/cs/project/LC06030" target="_blank" >LC06030: Biomolekulární centrum</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinary Microbiology

ISSN

0378-1135

e-ISSN

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Svazek periodika

139

Číslo periodika v rámci svazku

3-4

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

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Kód UT WoS článku

000271775700013

EID výsledku v databázi Scopus

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