Differences in DNA damage and repair produced by systemic, hepatocarcinogenic and sarcomagenic dibenzocarbazole derivatives in a model of rat liver progenitor cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F09%3A%230000572" target="_blank" >RIV/00027162:_____/09:#0000572 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081707:_____/09:00345305

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Differences in DNA damage and repair produced by systemic, hepatocarcinogenic and sarcomagenic dibenzocarbazole derivatives in a model of rat liver progenitor cells

Popis výsledku v původním jazyce

This study is a follow-up of a previous investigation which suggested that the "stem-like" rat liver epithelial cells (WB-F344) may be a potential target cell population for the liver carcinogens 7H-dibenzo[c,g]carbazole (DBC) and 5,9-dimethyldibenzo[c,g]carbazole (DiMeDBC). We focused on the genotoxic effects generated by these dibenzocarbazoles in WB-F344 cells to better understand the cellular and molecular mechanisms involved in hepatocarcinogenesis. In our study, we determined level of DNA damage (DNA adduct formation, strand breaks, micronuclei formation, oxidative stress) caused by DBC and diMeDBC as compared with sarcomagen N-methyldibenzo[c,g]carbazole (N-MeDBC). We demonstrated qualitative differences in the DNA damage profiles produced by DBC and DiMeDBC in WB-F344 cells. Different lesions may trigger distinct cellular pathways involved in hepatocarcinogenesis. The low amount of DNA damage, together with an efficient repair, may explain the lack of hepatocarcinogenicity of N

Název v anglickém jazyce

Differences in DNA damage and repair produced by systemic, hepatocarcinogenic and sarcomagenic dibenzocarbazole derivatives in a model of rat liver progenitor cells

Popis výsledku anglicky

This study is a follow-up of a previous investigation which suggested that the "stem-like" rat liver epithelial cells (WB-F344) may be a potential target cell population for the liver carcinogens 7H-dibenzo[c,g]carbazole (DBC) and 5,9-dimethyldibenzo[c,g]carbazole (DiMeDBC). We focused on the genotoxic effects generated by these dibenzocarbazoles in WB-F344 cells to better understand the cellular and molecular mechanisms involved in hepatocarcinogenesis. In our study, we determined level of DNA damage (DNA adduct formation, strand breaks, micronuclei formation, oxidative stress) caused by DBC and diMeDBC as compared with sarcomagen N-methyldibenzo[c,g]carbazole (N-MeDBC). We demonstrated qualitative differences in the DNA damage profiles produced by DBC and DiMeDBC in WB-F344 cells. Different lesions may trigger distinct cellular pathways involved in hepatocarcinogenesis. The low amount of DNA damage, together with an efficient repair, may explain the lack of hepatocarcinogenicity of N

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis

ISSN

0027-5107

e-ISSN

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Svazek periodika

665

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

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Kód UT WoS článku

000266690200008

EID výsledku v databázi Scopus

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