Frequency of Aneuploidy Related to Age in Porcine Oocytes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F11%3A%230000729" target="_blank" >RIV/00027162:_____/11:#0000729 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985904:_____/11:00365035

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Frequency of Aneuploidy Related to Age in Porcine Oocytes

Popis výsledku v původním jazyce

It is generally accepted that mammalian oocytes are frequently suffering from chromosome segregation errors during meiosis I. For study of this phenomenon, we have employed comparative genomic hybridization (CGH) to study the frequency of aneuploidy in porcine oocytes, including rare oocytes obtained from aged animals. In contrast to the previous reports where conventional methods, such as chromosome spreads or FISH, were used to estimate frequency of aneuploidy, our results presented here show, that the frequency of this phenomenon was overestimated in porcine oocytes. Surprisingly, despite the results from human and mouse showing an increase in the frequency of aneuploidy with advanced maternal age, our results obtained by the most accurate method currently available for scoring the aneuploidy in oocytes indicated no increase in the frequency of aneuploidy even in oocytes from aged animals.

Název v anglickém jazyce

Frequency of Aneuploidy Related to Age in Porcine Oocytes

Popis výsledku anglicky

It is generally accepted that mammalian oocytes are frequently suffering from chromosome segregation errors during meiosis I. For study of this phenomenon, we have employed comparative genomic hybridization (CGH) to study the frequency of aneuploidy in porcine oocytes, including rare oocytes obtained from aged animals. In contrast to the previous reports where conventional methods, such as chromosome spreads or FISH, were used to estimate frequency of aneuploidy, our results presented here show, that the frequency of this phenomenon was overestimated in porcine oocytes. Surprisingly, despite the results from human and mouse showing an increase in the frequency of aneuploidy with advanced maternal age, our results obtained by the most accurate method currently available for scoring the aneuploidy in oocytes indicated no increase in the frequency of aneuploidy even in oocytes from aged animals.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PLOS ONE

ISSN

1932-6203

e-ISSN

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Svazek periodika

6

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

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Kód UT WoS článku

000290019400013

EID výsledku v databázi Scopus

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