Male obesity and age in relationship to semen parameters and sperm chromatin integrity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F11%3A%230000738" target="_blank" >RIV/00027162:_____/11:#0000738 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Male obesity and age in relationship to semen parameters and sperm chromatin integrity

Popis výsledku v původním jazyce

Obesity can adversely affect human health. While obesity can disturb the hormonal profile of the female organism and is associated with fertility loss, little is known about the effect of male obesity. Semen samples of 153 donors were selected from couples attending an infertility clinic, who had tried for 12 months or more to achieve pregnancy without success. Age and body mass index (BMI) of the men was recorded. Semen samples were assessed for volume, sperm concentration, motility and morphology. Sperm chromatin integrity was measured by sperm chromatin structure assay. Quality of sperm chromatin condensation was assessed by toluidine blue, aniline blue and chromomycin A3 staining. We can conclude that the impact of elevated BMI on the parameters investigated was not proven. On the other hand, ejaculate quality appeared to be affected by ageing. The impact was reflected by chromatin integrity, which is a factor that can substantially affect fertility in men, rather than by basic spe

Název v anglickém jazyce

Male obesity and age in relationship to semen parameters and sperm chromatin integrity

Popis výsledku anglicky

Obesity can adversely affect human health. While obesity can disturb the hormonal profile of the female organism and is associated with fertility loss, little is known about the effect of male obesity. Semen samples of 153 donors were selected from couples attending an infertility clinic, who had tried for 12 months or more to achieve pregnancy without success. Age and body mass index (BMI) of the men was recorded. Semen samples were assessed for volume, sperm concentration, motility and morphology. Sperm chromatin integrity was measured by sperm chromatin structure assay. Quality of sperm chromatin condensation was assessed by toluidine blue, aniline blue and chromomycin A3 staining. We can conclude that the impact of elevated BMI on the parameters investigated was not proven. On the other hand, ejaculate quality appeared to be affected by ageing. The impact was reflected by chromatin integrity, which is a factor that can substantially affect fertility in men, rather than by basic spe

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Andrologia

ISSN

0303-4569

e-ISSN

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Svazek periodika

43

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

286-291

Kód UT WoS článku

000292393000011

EID výsledku v databázi Scopus

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