Host response in rabbits to infection with Pasteurella multocida serogroup F strains originating from fowl cholera

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F11%3A%230000745" target="_blank" >RIV/00027162:_____/11:#0000745 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Host response in rabbits to infection with Pasteurella multocida serogroup F strains originating from fowl cholera

Popis výsledku v původním jazyce

The ability of two avian P. multocida serogroup F strains to induce disease in rabbits was investigated. Two groups of 18 Pasteurella-free rabbits each were intranasally challenged with strains isolated from chickens and turkeys respectively. Half of theanimals in each challenge group were immunosuppressed using dexamethasone. All the challenged rabbits exhibited clinical signs of peracute septicaemic disease, ending with shock, and died or were euthanased in the terminal stages of the disease 1-2 dayspost-infection. Gross pathological changes included systemic vascular collapse and vascular leak syndrome. Hyperaemia, haemorrhage, oedema, inflammatory cell infiltrates, focal necrosis and degenerative changes were observed histologically in parenchymatous organs. This is the first study directly demonstrating that avian P. multocida serogroup F strains are highly virulent in rabbits and that avian hosts cannot be excluded as a possible source of rabbit infection with serogroup F.

Název v anglickém jazyce

Host response in rabbits to infection with Pasteurella multocida serogroup F strains originating from fowl cholera

Popis výsledku anglicky

The ability of two avian P. multocida serogroup F strains to induce disease in rabbits was investigated. Two groups of 18 Pasteurella-free rabbits each were intranasally challenged with strains isolated from chickens and turkeys respectively. Half of theanimals in each challenge group were immunosuppressed using dexamethasone. All the challenged rabbits exhibited clinical signs of peracute septicaemic disease, ending with shock, and died or were euthanased in the terminal stages of the disease 1-2 dayspost-infection. Gross pathological changes included systemic vascular collapse and vascular leak syndrome. Hyperaemia, haemorrhage, oedema, inflammatory cell infiltrates, focal necrosis and degenerative changes were observed histologically in parenchymatous organs. This is the first study directly demonstrating that avian P. multocida serogroup F strains are highly virulent in rabbits and that avian hosts cannot be excluded as a possible source of rabbit infection with serogroup F.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FN - Epidemiologie, infekční nemoci a klinická imunologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Canadian Journal of Veterinary Research-REVUE CANADIENNE DE RECHERCHE VETERINAIRE

ISSN

0830-9000

e-ISSN

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Svazek periodika

75

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CA - Kanada

Počet stran výsledku

9

Strana od-do

200-208

Kód UT WoS článku

000299528000006

EID výsledku v databázi Scopus

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