Immune Response of Chicken Gut to Natural Colonization by Gut Microflora and to Salmonella enterica Serovar Enteritidis Infection

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F11%3A%230000777" target="_blank" >RIV/00027162:_____/11:#0000777 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Immune Response of Chicken Gut to Natural Colonization by Gut Microflora and to Salmonella enterica Serovar Enteritidis Infection

Popis výsledku v původním jazyce

In this work we were interested in the development of the gut microbial community, the immune response to natural microbial colonization, and the response to Salmonella Enteritidis infection as a function of chicken age. The complexity of chicken gut microbiota gradually increased from day 1 to day 19 of life. For the first 3 days of life, chicken cecum showed increased expression of chicken beta-defensins, and then dropped. On the other hand, an increase in IL-8 and IL-17 expression was observed in chicken cecum on day 4 of life, indicating physiological inflammation and maturation of the gut immune system. In agreement, the response of chickens infected with S. Enteritidis on days 1, 4, and 16 of life shifted from Th1 (induction of IFN-gamma and iNOS), observed in younger chickens, to Th17, observed in 16-day-old chickens (induction of IL-17). Active modification of chicken gut microbiota in the future may influence the maturation of the gut immune system and increase its resistance

Název v anglickém jazyce

Immune Response of Chicken Gut to Natural Colonization by Gut Microflora and to Salmonella enterica Serovar Enteritidis Infection

Popis výsledku anglicky

In this work we were interested in the development of the gut microbial community, the immune response to natural microbial colonization, and the response to Salmonella Enteritidis infection as a function of chicken age. The complexity of chicken gut microbiota gradually increased from day 1 to day 19 of life. For the first 3 days of life, chicken cecum showed increased expression of chicken beta-defensins, and then dropped. On the other hand, an increase in IL-8 and IL-17 expression was observed in chicken cecum on day 4 of life, indicating physiological inflammation and maturation of the gut immune system. In agreement, the response of chickens infected with S. Enteritidis on days 1, 4, and 16 of life shifted from Th1 (induction of IFN-gamma and iNOS), observed in younger chickens, to Th17, observed in 16-day-old chickens (induction of IL-17). Active modification of chicken gut microbiota in the future may influence the maturation of the gut immune system and increase its resistance

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Infection and Immunity

ISSN

0019-9567

e-ISSN

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Svazek periodika

79

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

2755-2763

Kód UT WoS článku

000291788700027

EID výsledku v databázi Scopus

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