Association of the transcription profile of bovine oocytes and embryos with developmental potential
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F12%3A%230000928" target="_blank" >RIV/00027162:_____/12:#0000928 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/67985904:_____/12:00386817
Výsledek na webu
<a href="http://dx.doi.org/10.1016/j.anireprosci.2012.08.008" target="_blank" >http://dx.doi.org/10.1016/j.anireprosci.2012.08.008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.anireprosci.2012.08.008" target="_blank" >10.1016/j.anireprosci.2012.08.008</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Association of the transcription profile of bovine oocytes and embryos with developmental potential
Popis výsledku v původním jazyce
Although improvements in culture system have enhanced in vitro embryo production, success rates are still not adequate. The reasons for developmental arrest of a part of in vitro produced embryos are unknown, but are connected in part with low cytoplasmic competence of oocytes. The immaturity of cytoplasm can negatively influence fertilization efficiency and subsequent progression through embryonic genome activation (EGA), which are necessary steps in further pre-implantation development. A large numberof studies have compared mRNA abundance among oocytes with different developmental competence with the aim to find markers of the normal embryo development. The amount of mitochondrial DNA (mtDNA) and mRNA for mitochondrial transcriptional factors directing oxidative phosphorylation belongs to such promising markers. Nevertheless, recently published studies revealed that the mammalian embryo is able to compensate for a reduced level of mtDNA in oocyte during subsequent pre-implantation
Název v anglickém jazyce
Association of the transcription profile of bovine oocytes and embryos with developmental potential
Popis výsledku anglicky
Although improvements in culture system have enhanced in vitro embryo production, success rates are still not adequate. The reasons for developmental arrest of a part of in vitro produced embryos are unknown, but are connected in part with low cytoplasmic competence of oocytes. The immaturity of cytoplasm can negatively influence fertilization efficiency and subsequent progression through embryonic genome activation (EGA), which are necessary steps in further pre-implantation development. A large numberof studies have compared mRNA abundance among oocytes with different developmental competence with the aim to find markers of the normal embryo development. The amount of mitochondrial DNA (mtDNA) and mRNA for mitochondrial transcriptional factors directing oxidative phosphorylation belongs to such promising markers. Nevertheless, recently published studies revealed that the mammalian embryo is able to compensate for a reduced level of mtDNA in oocyte during subsequent pre-implantation
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Animal Reproduction Science
ISSN
0378-4320
e-ISSN
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Svazek periodika
134
Číslo periodika v rámci svazku
1-2
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
7
Strana od-do
29-35
Kód UT WoS článku
000309443100005
EID výsledku v databázi Scopus
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