Fibrin targeting enable thrombus imaging

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F18%3AN0000095" target="_blank" >RIV/00027162:_____/18:N0000095 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sci.muni.cz/orion/Setkani/Setkani19/index.htm" target="_blank" >http://www.sci.muni.cz/orion/Setkani/Setkani19/index.htm</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Fibrin targeting enable thrombus imaging

Popis výsledku v původním jazyce

XIX. Meeting of Biochemists and Molecular Biologists, Brno, 13.-14. November 2018. Ischemic stroke is leading cause of mortality and morbidity with serious socioeconomic impact. The occlusion blocking the blood flow is formed by a clot. Imaging methods like CTA show brain arteries with flow and arteries without flow are missing. The better imaging methods can lead to more precise treatment such as better targeting of stent retrievers as well as improvement in diagnosis of other thromboembolic events like pulmonary embolism and leg ischemia. As a first step to achieve patients’ clot imaging we employed in vitro models. Simple static models were used for fast screening. Sophisticated flow models mimicking average size of middle cerebral artery were used for selected binders targeting fibrin. The binders were bound to allophykocyanin or liposomes with rhodamin enabling their visualization by microscopy methods.

Název v anglickém jazyce

Fibrin targeting enable thrombus imaging

Popis výsledku anglicky

XIX. Meeting of Biochemists and Molecular Biologists, Brno, 13.-14. November 2018. Ischemic stroke is leading cause of mortality and morbidity with serious socioeconomic impact. The occlusion blocking the blood flow is formed by a clot. Imaging methods like CTA show brain arteries with flow and arteries without flow are missing. The better imaging methods can lead to more precise treatment such as better targeting of stent retrievers as well as improvement in diagnosis of other thromboembolic events like pulmonary embolism and leg ischemia. As a first step to achieve patients’ clot imaging we employed in vitro models. Simple static models were used for fast screening. Sophisticated flow models mimicking average size of middle cerebral artery were used for selected binders targeting fibrin. The binders were bound to allophykocyanin or liposomes with rhodamin enabling their visualization by microscopy methods.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30107 - Medicinal chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů