Virology

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F18%3AN0000251" target="_blank" >RIV/00027162:_____/18:N0000251 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60077344:_____/17:00485360

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Virology

Popis výsledku v původním jazyce

TBEV is the most medically important member of the tick-borne serocomplex group within the genus Flavivirus, family Flaviviridae.nThree antigenic subtypes of TBEV correspond to the 3 recognized genotypes: Western, also known as European, Far Eastern, and Siberian. An additional 2 genotypes have been identified in the Irkutsk region of Russia.nTBEV virions are small enveloped spherical particles about 50 nm in diameter.nThe TBEV genome consists of a single-stranded positive sense RNA molecule.nThe genome encodes one open reading frame (ORF), which is flanked by untranslated (non-coding) regions (UTRs).nThe 5′-UTR end has a methylated nucleotide cap for canonical cellular translation. The 3′-UTR is not polyadenylated and is characterized by extensive length and sequence heterogeneity.nThe ORF encodes one large polyprotein, which is co- and post-translationally cleaved into 3 structural proteins (C, prM, and E) and 7 non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5).nTBEV replicates in the cytoplasm of the host cell in close association with virus-induced intracellular membrane structures. Virus assembly occurs at the endoplasmic reticulum. The immature virions are transported to the Golgi complex, and mature virions pass through the host secretory pathway and are finally released from the host cell by fusion of the transport vesicle membrane with the plasma membrane.

Název v anglickém jazyce

Virology

Popis výsledku anglicky

TBEV is the most medically important member of the tick-borne serocomplex group within the genus Flavivirus, family Flaviviridae.nThree antigenic subtypes of TBEV correspond to the 3 recognized genotypes: Western, also known as European, Far Eastern, and Siberian. An additional 2 genotypes have been identified in the Irkutsk region of Russia.nTBEV virions are small enveloped spherical particles about 50 nm in diameter.nThe TBEV genome consists of a single-stranded positive sense RNA molecule.nThe genome encodes one open reading frame (ORF), which is flanked by untranslated (non-coding) regions (UTRs).nThe 5′-UTR end has a methylated nucleotide cap for canonical cellular translation. The 3′-UTR is not polyadenylated and is characterized by extensive length and sequence heterogeneity.nThe ORF encodes one large polyprotein, which is co- and post-translationally cleaved into 3 structural proteins (C, prM, and E) and 7 non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5).nTBEV replicates in the cytoplasm of the host cell in close association with virus-induced intracellular membrane structures. Virus assembly occurs at the endoplasmic reticulum. The immature virions are transported to the Golgi complex, and mature virions pass through the host secretory pathway and are finally released from the host cell by fusion of the transport vesicle membrane with the plasma membrane.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

10607 - Virology

Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Tick-Borne Encephalitis (TBE)

ISBN

978-981-11-1903-3

Počet stran výsledku

15

Strana od-do

12-26

Počet stran knihy

304

Název nakladatele

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Místo vydání

Singapore

Kód UT WoS kapitoly

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