Colon Cancer and Perturbations of the Sphingolipid Metabolism

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F19%3AN0000177" target="_blank" >RIV/00027162:_____/19:N0000177 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081707:_____/19:00520477

Výsledek na webu

<a href="https://www.mdpi.com/1422-0067/20/23/6051" target="_blank" >https://www.mdpi.com/1422-0067/20/23/6051</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms20236051" target="_blank" >10.3390/ijms20236051</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Colon Cancer and Perturbations of the Sphingolipid Metabolism

Popis výsledku v původním jazyce

Colon Cancer and Perturbations of theSphingolipid Metabolism - The development and progression of colorectal cancer (CRC), a major cause of cancer-relateddeath in the western world, is accompanied with alterations of sphingolipid (SL) composition in colontumors. A number of enzymes involved in the SL metabolism have been found to be deregulatedin human colon tumors, in experimental rodent studies, and in human colon cancer cellsin vitro.Therefore, the enzymatic pathways that modulate SL levels have received a significant attention, due to their possible contribution to CRC development, or as potential therapeutic targets. Many of theseenzymes are associated with an increased sphingosine-1-phosphate/ceramide ratio, which is in turnlinked with increased colon cancer cell survival, proliferation and cancer progression. Nevertheless,more attention should also be paid to the more complex SLs, including specific glycosphingolipids,such as lactosylceramides, which can be also deregulated during CRC development. In this review,we focus on the potential roles of individual SLs/SL metabolism enzymes in colon cancer, as wellas on the pros and cons of employing the current in vitro models of colon cancer cells for lipidomicstudies investigating the SL metabolism in CRC.

Název v anglickém jazyce

Colon Cancer and Perturbations of the Sphingolipid Metabolism

Popis výsledku anglicky

Colon Cancer and Perturbations of theSphingolipid Metabolism - The development and progression of colorectal cancer (CRC), a major cause of cancer-relateddeath in the western world, is accompanied with alterations of sphingolipid (SL) composition in colontumors. A number of enzymes involved in the SL metabolism have been found to be deregulatedin human colon tumors, in experimental rodent studies, and in human colon cancer cellsin vitro.Therefore, the enzymatic pathways that modulate SL levels have received a significant attention, due to their possible contribution to CRC development, or as potential therapeutic targets. Many of theseenzymes are associated with an increased sphingosine-1-phosphate/ceramide ratio, which is in turnlinked with increased colon cancer cell survival, proliferation and cancer progression. Nevertheless,more attention should also be paid to the more complex SLs, including specific glycosphingolipids,such as lactosylceramides, which can be also deregulated during CRC development. In this review,we focus on the potential roles of individual SLs/SL metabolism enzymes in colon cancer, as wellas on the pros and cons of employing the current in vitro models of colon cancer cells for lipidomicstudies investigating the SL metabolism in CRC.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30107 - Medicinal chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Molecular Sciences

ISSN

1422-0067

e-ISSN

—

Svazek periodika

20

Číslo periodika v rámci svazku

23

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

14

Strana od-do

6051

Kód UT WoS článku

000504428300233

EID výsledku v databázi Scopus

—