Lab on a Chip Approach to Develop System Predicting Stenosis Stability

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F19%3AN0000287" target="_blank" >RIV/00027162:_____/19:N0000287 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Lab on a Chip Approach to Develop System Predicting Stenosis Stability

Popis výsledku v původním jazyce

Thromboembolic diseases like ischemic stroke are leading causes of mortality and morbidity worldwide. Internal carotid stenosis with unstable atherosclerotic plaque is an important condition often leading to the ischemic stroke. Nowadays it is still unclear why some plaques are stable and other unstable creating thromboembolus (thus ischemic stroke). A prediction of plaque stability could help in surgery decision making. We considered the lab on a chip approach with creation of in vitro carotid models with stenosis based on patient’s data. Further, we established physiological flow in the models and studied hemodynamic parameters in healthy parts of carotids and with atherosclerotic plaques. Biochemical surface modifications of models were also considered.

Název v anglickém jazyce

Lab on a Chip Approach to Develop System Predicting Stenosis Stability

Popis výsledku anglicky

Thromboembolic diseases like ischemic stroke are leading causes of mortality and morbidity worldwide. Internal carotid stenosis with unstable atherosclerotic plaque is an important condition often leading to the ischemic stroke. Nowadays it is still unclear why some plaques are stable and other unstable creating thromboembolus (thus ischemic stroke). A prediction of plaque stability could help in surgery decision making. We considered the lab on a chip approach with creation of in vitro carotid models with stenosis based on patient’s data. Further, we established physiological flow in the models and studied hemodynamic parameters in healthy parts of carotids and with atherosclerotic plaques. Biochemical surface modifications of models were also considered.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10609 - Biochemical research methods

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů