The impact of parturition induction with cloprostenol on immunological parameters in the sow colostrum

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F20%3AN0000200" target="_blank" >RIV/00027162:_____/20:N0000200 - isvavai.cz</a>

Výsledek na webu

<a href="https://porcinehealthmanagement.biomedcentral.com/articles/10.1186/s40813-020-00174-y" target="_blank" >https://porcinehealthmanagement.biomedcentral.com/articles/10.1186/s40813-020-00174-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s40813-020-00174-y" target="_blank" >10.1186/s40813-020-00174-y</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The impact of parturition induction with cloprostenol on immunological parameters in the sow colostrum

Popis výsledku v původním jazyce

Background Farrowing induction with prostaglandin F2 analogue cloprostenol is commonly used on commercial farms to manage the timing of farrowing. When labour induction is applied, the questions arise about possible side effects of such a hormonal intervention on physiological processes connected with labour and lactation, including colostral immunity. Results In this study, immune cells composition, lysozyme concentration, complement bacteriolytic activity and proinflamatory (GM-CSF2, IL-1 beta, IL-6, a TNF alpha) and anti-inflammatory (IL-4, IL-10, TGF beta 1 a TGF beta 2) cytokines were measured in colostrum samples from sows farrowing naturally (NP) and from sows with farrowing induced using cloprostenol administration on day 113 of gestation (IP). A significantly higher proportion of lymphocytes was found in colostrum of induced sows compared to colostrum of non-induced sows. No significant differences between NP and IP were found in complement activity, in the proportions of granulocytes, macrophages and lymphocyte subpopulations. Lower lysozyme concentration and higher IL-1 beta, IL-6, TGF beta 1 and TNF alpha concentrations were found in IP sow colostrum compared to colostrum from NP sows. Conclusions An increased proportion of colostral lymphocytes can positively influence the cellular immunity transmission from sow to her offspring. On the other hand, a lower lysozyme concentration can adversely affect newborn's intestinal immunity, as well as changes in cytokine concentrations can have an adverse effect on newborn piglet intestinal epithelium development and its defence function.

Název v anglickém jazyce

The impact of parturition induction with cloprostenol on immunological parameters in the sow colostrum

Popis výsledku anglicky

Background Farrowing induction with prostaglandin F2 analogue cloprostenol is commonly used on commercial farms to manage the timing of farrowing. When labour induction is applied, the questions arise about possible side effects of such a hormonal intervention on physiological processes connected with labour and lactation, including colostral immunity. Results In this study, immune cells composition, lysozyme concentration, complement bacteriolytic activity and proinflamatory (GM-CSF2, IL-1 beta, IL-6, a TNF alpha) and anti-inflammatory (IL-4, IL-10, TGF beta 1 a TGF beta 2) cytokines were measured in colostrum samples from sows farrowing naturally (NP) and from sows with farrowing induced using cloprostenol administration on day 113 of gestation (IP). A significantly higher proportion of lymphocytes was found in colostrum of induced sows compared to colostrum of non-induced sows. No significant differences between NP and IP were found in complement activity, in the proportions of granulocytes, macrophages and lymphocyte subpopulations. Lower lysozyme concentration and higher IL-1 beta, IL-6, TGF beta 1 and TNF alpha concentrations were found in IP sow colostrum compared to colostrum from NP sows. Conclusions An increased proportion of colostral lymphocytes can positively influence the cellular immunity transmission from sow to her offspring. On the other hand, a lower lysozyme concentration can adversely affect newborn's intestinal immunity, as well as changes in cytokine concentrations can have an adverse effect on newborn piglet intestinal epithelium development and its defence function.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40301 - Veterinary science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PORCINE HEALTH MANAGEMENT

ISSN

2055-5660

e-ISSN

2055-5660

Svazek periodika

6

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

"35"

Kód UT WoS článku

000597627800001

EID výsledku v databázi Scopus

2-s2.0-85097374030