The effects of age on DNA fragmentation, the condensation of chromatin and conventional semen parameters in healthy nonsmoking men exposed to traffic air pollution

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F21%3AN0000075" target="_blank" >RIV/00027162:_____/21:N0000075 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/21:00560388

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1002/hsr2.260" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/hsr2.260</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/hsr2.260" target="_blank" >10.1002/hsr2.260</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The effects of age on DNA fragmentation, the condensation of chromatin and conventional semen parameters in healthy nonsmoking men exposed to traffic air pollution

Popis výsledku v původním jazyce

Impact of age on semen quality was studied in healthy nonsmoking men. Semen samples from 150 Prague City policemen aged 23-63 years were examined for standard semen parameters, sperm DNA fragmentation and high DNA stainability. A significant positive correlation was found between age and %DFI (r = 0.359, p  0.001), and negative correlations were found between age and sperm vitality (r = -0.247, p  0.001), the % acrosome-intact sperm (r = -0.202, p = 0.013) and the % normal sperm heads (r = -0.204, p=0.012). A weak but significant negative correlation was found for high DNA stainability (% HDS) vs. age (r = -0.161, p = 0.050). No significant correlation was detected between male age and the other investigated semen quality parameters. At ages of 23-30, 31-40, 41-50, and 51-63 years, the mean %DFI values were 12.7±7.18, 14.7±7.42, 19.6±11.25, and 34.2±15.08, respectively. Our study shows a strong relationship (p < 0.001) between the age of men and sperm DNA fragmentation in an occupational cohort at risk of exposure to heavy traffic-related air pollution in a large city centre.

Název v anglickém jazyce

The effects of age on DNA fragmentation, the condensation of chromatin and conventional semen parameters in healthy nonsmoking men exposed to traffic air pollution

Popis výsledku anglicky

Impact of age on semen quality was studied in healthy nonsmoking men. Semen samples from 150 Prague City policemen aged 23-63 years were examined for standard semen parameters, sperm DNA fragmentation and high DNA stainability. A significant positive correlation was found between age and %DFI (r = 0.359, p  0.001), and negative correlations were found between age and sperm vitality (r = -0.247, p  0.001), the % acrosome-intact sperm (r = -0.202, p = 0.013) and the % normal sperm heads (r = -0.204, p=0.012). A weak but significant negative correlation was found for high DNA stainability (% HDS) vs. age (r = -0.161, p = 0.050). No significant correlation was detected between male age and the other investigated semen quality parameters. At ages of 23-30, 31-40, 41-50, and 51-63 years, the mean %DFI values were 12.7±7.18, 14.7±7.42, 19.6±11.25, and 34.2±15.08, respectively. Our study shows a strong relationship (p < 0.001) between the age of men and sperm DNA fragmentation in an occupational cohort at risk of exposure to heavy traffic-related air pollution in a large city centre.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

10604 - Reproductive biology (medical aspects to be 3)

Projekt

<a href="/cs/project/EF16_019%2F0000798" target="_blank" >EF16_019/0000798: Healthy Aging in Industrial Environment HAIE</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Health Science Reports

ISSN

2398-8835

e-ISSN

—

Svazek periodika

4

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

—

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85108961684