Foodborne fluoxetine impacts the immune response in rainbow trout (Oncorhynchus mykkis)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F22%3AN0000011" target="_blank" >RIV/00027162:_____/22:N0000011 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62156489:43210/22:43921042 RIV/00216224:14160/22:00125799 RIV/62157124:16170/22:43880318 RIV/62157124:16270/22:43880318

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1382668922000114" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1382668922000114</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.etap.2022.103818" target="_blank" >10.1016/j.etap.2022.103818</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Foodborne fluoxetine impacts the immune response in rainbow trout (Oncorhynchus mykkis)

Popis výsledku v původním jazyce

The aim of this study was to reveal the effects of foodborne fluoxetine on morphological and condition profile, haematological profile, biochemical and oxidative stress indices on juvenile rainbow trout. The study was performed according to OECD Guideline No. 215. Fluoxetine was incorporated into Biomar 921 pellets at a dose of 0.047 mg/kg (environmental concentration), 0.577 mg/kg and 6.7 mg/kg. There was statistically significant change in haematological profile, including an increasing trend in neutrophil/lymphocyte ratio and a decreasing trend in the number of lymphocytes. Measurements of oxidative stress indicated decreased activity of the detoxifying enzyme glutathione-S-transferase in the liver and kidney. However, the measurement of GR, GPx, CAT, SOD activity, and TBARS showed no changes. Histopathological examination revealed damage to the proximal tubules of caudal kidney in exposed groups. This study confirms that fluoxetine has a significant effect on immune response.

Název v anglickém jazyce

Foodborne fluoxetine impacts the immune response in rainbow trout (Oncorhynchus mykkis)

Popis výsledku anglicky

The aim of this study was to reveal the effects of foodborne fluoxetine on morphological and condition profile, haematological profile, biochemical and oxidative stress indices on juvenile rainbow trout. The study was performed according to OECD Guideline No. 215. Fluoxetine was incorporated into Biomar 921 pellets at a dose of 0.047 mg/kg (environmental concentration), 0.577 mg/kg and 6.7 mg/kg. There was statistically significant change in haematological profile, including an increasing trend in neutrophil/lymphocyte ratio and a decreasing trend in the number of lymphocytes. Measurements of oxidative stress indicated decreased activity of the detoxifying enzyme glutathione-S-transferase in the liver and kidney. However, the measurement of GR, GPx, CAT, SOD activity, and TBARS showed no changes. Histopathological examination revealed damage to the proximal tubules of caudal kidney in exposed groups. This study confirms that fluoxetine has a significant effect on immune response.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30108 - Toxicology

Projekt

<a href="/cs/project/EF16_019%2F0000869" target="_blank" >EF16_019/0000869: Udržitelná produkce zdravých ryb v různých akvakulturních systémech - PROFISH</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Toxicology and Pharmacology

ISSN

1382-6689

e-ISSN

1872-7077

Svazek periodika

90

Číslo periodika v rámci svazku

February 2022

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

—

Kód UT WoS článku

000788239300001

EID výsledku v databázi Scopus

2-s2.0-85123636132