Controlled synthesis of gemini surfactant-capped gold nanoparticles. Gemini structure-nanoparticle properties relationship study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F22%3AN0000093" target="_blank" >RIV/00027162:_____/22:N0000093 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26310/22:PU146989

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0167732222017494?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0167732222017494?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.molliq.2022.120210" target="_blank" >10.1016/j.molliq.2022.120210</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Controlled synthesis of gemini surfactant-capped gold nanoparticles. Gemini structure-nanoparticle properties relationship study

Popis výsledku v původním jazyce

Gold nanoparticles were prepared by the method of chemical reduction utilising sodium borohydride as reducing agent and stabilised with bisammonium gemini surfactants with variable length of poly methylene spacer. Physico-chemical investigations indicated the presence of plasmon resonance peaks in the wavelength range 507–544 nm for all investigated Au nanodispersions. The nanoparticle size anal ysis shows the relationship between the size of gold nanoparticles and the spacer length of stabilising gemini molecules. The strong aggregation tendency of gemini surfactants with short polymethylene spacer composed of 2–4 methylene units in aqueous solutions may be responsible for the formation of clusters of gold nanoparticles which results in the observed large hydrodynamic size of nanoparticle clus ters at the surfactants concentrations below the CMC. At higher surfactant-to-gold molar ratio values, clusters disintegration occurs and the decrease in size of the nanoparticles is observed. The shape of gold nanoparticles was found to be spherical and polyhedral, as evidenced by the SEM images. The size values varied between 30–60 nm and 10–15 nm for AuNPs capped with gemini molecules with short and medium/long spacer, respectively. Gold nanoparticles are strongly positively charged, with positive zeta potential values being in the interval +44 to +90 mV in the whole analysed region of molar ratio values and surfactant spacer length. The biological experiments indicate a dependence of biological activity of gold nanoparticles on the structural parameter (spacer length) of stabilising gemini molecules. Both cyto toxicity and anti-inflammatory activity of gold nanoparticles were found to increase with the increasing gemini spacer length up to 12 methylene groups in the spacer.

Název v anglickém jazyce

Controlled synthesis of gemini surfactant-capped gold nanoparticles. Gemini structure-nanoparticle properties relationship study

Popis výsledku anglicky

Gold nanoparticles were prepared by the method of chemical reduction utilising sodium borohydride as reducing agent and stabilised with bisammonium gemini surfactants with variable length of poly methylene spacer. Physico-chemical investigations indicated the presence of plasmon resonance peaks in the wavelength range 507–544 nm for all investigated Au nanodispersions. The nanoparticle size anal ysis shows the relationship between the size of gold nanoparticles and the spacer length of stabilising gemini molecules. The strong aggregation tendency of gemini surfactants with short polymethylene spacer composed of 2–4 methylene units in aqueous solutions may be responsible for the formation of clusters of gold nanoparticles which results in the observed large hydrodynamic size of nanoparticle clus ters at the surfactants concentrations below the CMC. At higher surfactant-to-gold molar ratio values, clusters disintegration occurs and the decrease in size of the nanoparticles is observed. The shape of gold nanoparticles was found to be spherical and polyhedral, as evidenced by the SEM images. The size values varied between 30–60 nm and 10–15 nm for AuNPs capped with gemini molecules with short and medium/long spacer, respectively. Gold nanoparticles are strongly positively charged, with positive zeta potential values being in the interval +44 to +90 mV in the whole analysed region of molar ratio values and surfactant spacer length. The biological experiments indicate a dependence of biological activity of gold nanoparticles on the structural parameter (spacer length) of stabilising gemini molecules. Both cyto toxicity and anti-inflammatory activity of gold nanoparticles were found to increase with the increasing gemini spacer length up to 12 methylene groups in the spacer.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30107 - Medicinal chemistry

Projekt

<a href="/cs/project/EF15_003%2F0000495" target="_blank" >EF15_003/0000495: FIT (Farmakologie, Imunoterapie, nanoToxikologie)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Molecular Liquids

ISSN

0167-7322

e-ISSN

1873-3166

Svazek periodika

365

Číslo periodika v rámci svazku

1 November 2022

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

13

Strana od-do

—

Kód UT WoS článku

000861204500008

EID výsledku v databázi Scopus

2-s2.0-85137167080