Staphylococcus aureus Burn Wound Infection: treatment perspectives with enzybiotics in topical administration

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F22%3AN0000258" target="_blank" >RIV/00027162:_____/22:N0000258 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Staphylococcus aureus Burn Wound Infection: treatment perspectives with enzybiotics in topical administration

Popis výsledku v původním jazyce

Infectious complications play a crucial role in morbidity and mortality in patients with thermal injury. The compromisation of the local barrier, together with the presence of necrotic tissue and specific immunoparalysis in these patients, causes very rapid propagation of pathogens into the deeper layers and the development of local infection or systemic sepsis. Commonly as in other patients with critical illness, there is a very well documented increasing trend in antimicrobial resistance. The only way how we can manage the increasing resistance of pathogens is to extend the spectrum of available antimicrobials and reduce selective pressure. One of the most promising options is the application of antibacterial enzymes called "enzybiotics" derived from the enzymatic machinery of bacteriophages (endolysins) or competitive bacteria (e.g. lysostaphin). Within in vitro testing, we evaluated 13 different sequence types of methicillin-resistant Staphylococcus aureus strains epidemiologically relevant for burned patients. Most of these tested strains were sensitive to lysostaphin. However, during in vitro testing, we identified a few strains that were sensitive only to higher concentrations of enzymes.

Název v anglickém jazyce

Staphylococcus aureus Burn Wound Infection: treatment perspectives with enzybiotics in topical administration

Popis výsledku anglicky

Infectious complications play a crucial role in morbidity and mortality in patients with thermal injury. The compromisation of the local barrier, together with the presence of necrotic tissue and specific immunoparalysis in these patients, causes very rapid propagation of pathogens into the deeper layers and the development of local infection or systemic sepsis. Commonly as in other patients with critical illness, there is a very well documented increasing trend in antimicrobial resistance. The only way how we can manage the increasing resistance of pathogens is to extend the spectrum of available antimicrobials and reduce selective pressure. One of the most promising options is the application of antibacterial enzymes called "enzybiotics" derived from the enzymatic machinery of bacteriophages (endolysins) or competitive bacteria (e.g. lysostaphin). Within in vitro testing, we evaluated 13 different sequence types of methicillin-resistant Staphylococcus aureus strains epidemiologically relevant for burned patients. Most of these tested strains were sensitive to lysostaphin. However, during in vitro testing, we identified a few strains that were sensitive only to higher concentrations of enzymes.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30303 - Infectious Diseases

Projekt

<a href="/cs/project/NV19-05-00214" target="_blank" >NV19-05-00214: Studium terapeutické aplikace antibakteriálního krytí rány pro infekce kůže a měkkých tkání u epidemiologicky relevantních kmenů S. aureus - rezistentních na meticilin.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů