Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F23%3AN0000021" target="_blank" >RIV/00027162:_____/23:N0000021 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26620/23:PU147336 RIV/60077344:_____/22:00580525 RIV/00216224:14310/23:00130535 RIV/62156489:43210/23:43922564 RIV/61989100:27240/23:10252773

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1002/adhm.202202682" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/adhm.202202682</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/adhm.202202682" target="_blank" >10.1002/adhm.202202682</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract

Popis výsledku v původním jazyce

Magnetic microrobots offer wireless navigation capability in hard-to-reach areas of the human body for targeted therapeutics and diagnostics. Though in vivo imaging is required for guidance of the magnetic microrobots toward the target areas, most of the imaging techniques are inadequate to reveal the potential locomotion routes. Here, we propose the utilization of radiopaque magnetic microrobots along with micro-computed tomography (microCT) for localized in vivo imaging applications. The microrobots consist of a contrast agent, barium sulfate (BaSO4) microparticles, magnetized by a decoration with magnetite (Fe3O4) nanoparticles. The magnetic features lead to actuation under rotating magnetic fields and enable precise navigation in a microfluidic channel used to simulate confined spaces of the human body. Furthermore, the intrinsic radiopacity of the microrobots provides the possibility to reveal internal structures in vitro by generating X-ray contrast. In vivo experiments demonstrate localization of the microrobots in a specific part of the gastrointestinal (GI) tract upon the influence of the magnetic field, indicating the efficient control even in the presence of natural peristaltic movements. The microrobots reported here highlight that smart microrobotic contrast agents can improve the current imaging-based diagnostic techniques by providing untethered controllability in vivo.

Název v anglickém jazyce

Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract

Popis výsledku anglicky

Magnetic microrobots offer wireless navigation capability in hard-to-reach areas of the human body for targeted therapeutics and diagnostics. Though in vivo imaging is required for guidance of the magnetic microrobots toward the target areas, most of the imaging techniques are inadequate to reveal the potential locomotion routes. Here, we propose the utilization of radiopaque magnetic microrobots along with micro-computed tomography (microCT) for localized in vivo imaging applications. The microrobots consist of a contrast agent, barium sulfate (BaSO4) microparticles, magnetized by a decoration with magnetite (Fe3O4) nanoparticles. The magnetic features lead to actuation under rotating magnetic fields and enable precise navigation in a microfluidic channel used to simulate confined spaces of the human body. Furthermore, the intrinsic radiopacity of the microrobots provides the possibility to reveal internal structures in vitro by generating X-ray contrast. In vivo experiments demonstrate localization of the microrobots in a specific part of the gastrointestinal (GI) tract upon the influence of the magnetic field, indicating the efficient control even in the presence of natural peristaltic movements. The microrobots reported here highlight that smart microrobotic contrast agents can improve the current imaging-based diagnostic techniques by providing untethered controllability in vivo.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30404 - Biomaterials (as related to medical implants, devices, sensors)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Advanced Healthcare Materials

ISSN

2192-2640

e-ISSN

2192-2659

Svazek periodika

12

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

"2202682"

Kód UT WoS článku

000903078100001

EID výsledku v databázi Scopus

2-s2.0-85145028340