Carcinogenicity of perfluorooctanoic acid and perfluorooctanesulfonic acid

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F24%3AN0000003" target="_blank" >RIV/00027162:_____/24:N0000003 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1470204523006228?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1470204523006228?via%3Dihub</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Carcinogenicity of perfluorooctanoic acid and perfluorooctanesulfonic acid

Popis výsledku v původním jazyce

In November, 2023, a Working Group of 30 scientists from 11 countries met at the International Agency for Research on Cancer (IARC) in Lyon, France, to finalise their evaluation of the carcinogenicity of two agents: perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), including their corresponding isomers and salts. PFOA was classified as “carcinogenic to humans” (Group 1) based on “sufficient” evidence for cancer in experimental animals and “strong” mechanistic evidence in exposed humans. The evidence for cancer in experimental animals was “sufficient” because an increased incidence of an appropriate combination of benign and malignant neoplasms was observed in both sexes of a single species in a Good Laboratory Practice (GLP) study. PFOS was classified as “possibly carcinogenic to humans” (Group 2B) based on “strong” mechanistic evidence. The evidence for cancer in experimental animals was “limited” for PFOS, and the evidence regarding cancer in humans was “inadequate”. These assessments will be published in Volume 135 of the IARC Monographs.

Název v anglickém jazyce

Carcinogenicity of perfluorooctanoic acid and perfluorooctanesulfonic acid

Popis výsledku anglicky

In November, 2023, a Working Group of 30 scientists from 11 countries met at the International Agency for Research on Cancer (IARC) in Lyon, France, to finalise their evaluation of the carcinogenicity of two agents: perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), including their corresponding isomers and salts. PFOA was classified as “carcinogenic to humans” (Group 1) based on “sufficient” evidence for cancer in experimental animals and “strong” mechanistic evidence in exposed humans. The evidence for cancer in experimental animals was “sufficient” because an increased incidence of an appropriate combination of benign and malignant neoplasms was observed in both sexes of a single species in a Good Laboratory Practice (GLP) study. PFOS was classified as “possibly carcinogenic to humans” (Group 2B) based on “strong” mechanistic evidence. The evidence for cancer in experimental animals was “limited” for PFOS, and the evidence regarding cancer in humans was “inadequate”. These assessments will be published in Volume 135 of the IARC Monographs.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30304 - Public and environmental health

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

The Lancet Oncology

ISSN

1470-2045

e-ISSN

1474-5488

Svazek periodika

25

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

2

Strana od-do

16-17

Kód UT WoS článku

001154583000001

EID výsledku v databázi Scopus

2-s2.0-85181778127