Lipidomic analysis in xenobiochemistry and toxikology based on mass spectrometry

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F24%3AN0000176" target="_blank" >RIV/00027162:_____/24:N0000176 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Lipidomic analysis in xenobiochemistry and toxikology based on mass spectrometry

Popis výsledku v původním jazyce

Lipidomics, the detailed study of lipids within biological systems, has become indispensable in xenobiochemistry and toxicology, particularly through the application of mass spectrometry (MS). This powerful technique enables precise identification and quantification of diverse lipid species, offering critical insights into the effects of xenobiotics on lipid metabolism and cellular functions. MS-based lipidomics allows for the detection of subtle yet significant alterations in lipid profiles, including changes in phospholipids, sphingolipids, and eicosanoids. These alterations can illuminate the mechanisms by which xenobiotics induce cellular stress, toxicity, membrane disruption, lipid peroxidation, and inflammatory signaling. Such insights are essential for identifying reliable biomarkers of exposure and for elucidating the molecular pathways involved in xenobiotic interactions. The integration of mass spectrometry into lipidomic studies not only enhances the detection and prevention of toxic effects but also contributes to the development of novel strategies for mitigating the impact of xenobiotics on human health and deepening our understanding of biochemical pathways.

Název v anglickém jazyce

Lipidomic analysis in xenobiochemistry and toxikology based on mass spectrometry

Popis výsledku anglicky

Lipidomics, the detailed study of lipids within biological systems, has become indispensable in xenobiochemistry and toxicology, particularly through the application of mass spectrometry (MS). This powerful technique enables precise identification and quantification of diverse lipid species, offering critical insights into the effects of xenobiotics on lipid metabolism and cellular functions. MS-based lipidomics allows for the detection of subtle yet significant alterations in lipid profiles, including changes in phospholipids, sphingolipids, and eicosanoids. These alterations can illuminate the mechanisms by which xenobiotics induce cellular stress, toxicity, membrane disruption, lipid peroxidation, and inflammatory signaling. Such insights are essential for identifying reliable biomarkers of exposure and for elucidating the molecular pathways involved in xenobiotic interactions. The integration of mass spectrometry into lipidomic studies not only enhances the detection and prevention of toxic effects but also contributes to the development of novel strategies for mitigating the impact of xenobiotics on human health and deepening our understanding of biochemical pathways.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30108 - Toxicology

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů