Evaluating the anti-inflammatory potential of prenylated (iso)flavonoids from Ficus cyathistipulainan in vitromodel ofinflammatory response

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F24%3AN0000238" target="_blank" >RIV/00027162:_____/24:N0000238 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Evaluating the anti-inflammatory potential of prenylated (iso)flavonoids from Ficus cyathistipulainan in vitromodel ofinflammatory response

Popis výsledku v původním jazyce

Book of Abstracts: Trends in Natural Products 2024PSE Young Scientists' MeetingPhytochemical Society of Europe (PSE), 2 1 s t - 2 4 t h M a y 2 0 2 4 , B r n o , C z e c h R e p u b l i c, BIOACTIVE NATURAL PRODUCTS IN BIOLOGY,PHARMACY AND COSMETICS. In recent years, there has been renewed interest in natural treatments and plants as potential sources of new drugs for the treatment of inflammatory diseases. Prenylated phenolics, adiverse group of natural compounds found in various plants, are known for their significant anti-inflammatory potential. Therefore, roots of Ficuscyathistipula Warb. (Moraceae) were subjected to extensive chromatographic separation leading to the isolation of twelve prenylated (iso)flavonoids of which five compounds were isolated from plant material for the first time. Their potential anti-inflammatory effect was investigated in an in vitrostudy. The first screening was conducted on the human leukemia monocytic cell line THP1-Blue™NF-κB stimulated withlipopolysaccharide. The anti-inflammatory potential was evaluated as the inhibition of NF-κB, one of the key pro-inflammatory transcriptional factors, using the QUANTI-Blue™colorimetric enzyme assay. Results demonstrated that seven prenylated (iso)flavonoids showed the same or better effect on the inhibition of the NF-κB signaling pathway compared to the standard drug prednisolone. The inhibition of nuclear translocation of NF-kB, as one of the potential mechanisms of action, was investigated in the two most active compounds. The obtained results opened the door forfurther study of the anti-inflammatory potential of these compounds..

Název v anglickém jazyce

Evaluating the anti-inflammatory potential of prenylated (iso)flavonoids from Ficus cyathistipulainan in vitromodel ofinflammatory response

Popis výsledku anglicky

Book of Abstracts: Trends in Natural Products 2024PSE Young Scientists' MeetingPhytochemical Society of Europe (PSE), 2 1 s t - 2 4 t h M a y 2 0 2 4 , B r n o , C z e c h R e p u b l i c, BIOACTIVE NATURAL PRODUCTS IN BIOLOGY,PHARMACY AND COSMETICS. In recent years, there has been renewed interest in natural treatments and plants as potential sources of new drugs for the treatment of inflammatory diseases. Prenylated phenolics, adiverse group of natural compounds found in various plants, are known for their significant anti-inflammatory potential. Therefore, roots of Ficuscyathistipula Warb. (Moraceae) were subjected to extensive chromatographic separation leading to the isolation of twelve prenylated (iso)flavonoids of which five compounds were isolated from plant material for the first time. Their potential anti-inflammatory effect was investigated in an in vitrostudy. The first screening was conducted on the human leukemia monocytic cell line THP1-Blue™NF-κB stimulated withlipopolysaccharide. The anti-inflammatory potential was evaluated as the inhibition of NF-κB, one of the key pro-inflammatory transcriptional factors, using the QUANTI-Blue™colorimetric enzyme assay. Results demonstrated that seven prenylated (iso)flavonoids showed the same or better effect on the inhibition of the NF-κB signaling pathway compared to the standard drug prednisolone. The inhibition of nuclear translocation of NF-kB, as one of the potential mechanisms of action, was investigated in the two most active compounds. The obtained results opened the door forfurther study of the anti-inflammatory potential of these compounds..

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/NU22-08-00236" target="_blank" >NU22-08-00236: Preklinické studie neplatinových metaloléčiv v terapii rakoviny plic</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů