Dietary exposure to 17α-ethinylestradiol negatively affects reproduction and health parameters of zebrafish (Danio rerio)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F25%3AN0000048" target="_blank" >RIV/00027162:_____/25:N0000048 - isvavai.cz</a>

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1111/jfb.16065?af=R" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/jfb.16065?af=R</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jfb.16065" target="_blank" >10.1111/jfb.16065</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dietary exposure to 17α-ethinylestradiol negatively affects reproduction and health parameters of zebrafish (Danio rerio)

Popis výsledku v původním jazyce

Pollution of the aquatic ecosystem by hormone-active substances is a frequently discussed topic these days. Such substances can pass through the sewage treatment plant system and affect aquatic life. This study tested the effect of 17 alpha-ethinylestradiol (EE2) on individual zebrafish (Danio rerio) at an environmentally relevant concentration in fish food (10 mu g/kg) and at a concentration 100 times higher (1000 mu g/kg). This experiment revealed significant changes in the expression of reproductive genes, an increase in vitellogenin levels and histopathological lesions in the testes after EE2 exposure. Additionally, lipid peroxidation and changes in antioxidant enzyme activities were observed at both tested concentrations, along with morphological changes and increased mortality at the higher concentration. Even the environmentally relevant concentration of EE2 poses a danger to the aquatic organisms as it changes D. rerio's reproductive and health parameters, indicating toxicity at molecular, cell, tissue, and organism levels.

Název v anglickém jazyce

Dietary exposure to 17α-ethinylestradiol negatively affects reproduction and health parameters of zebrafish (Danio rerio)

Popis výsledku anglicky

Pollution of the aquatic ecosystem by hormone-active substances is a frequently discussed topic these days. Such substances can pass through the sewage treatment plant system and affect aquatic life. This study tested the effect of 17 alpha-ethinylestradiol (EE2) on individual zebrafish (Danio rerio) at an environmentally relevant concentration in fish food (10 mu g/kg) and at a concentration 100 times higher (1000 mu g/kg). This experiment revealed significant changes in the expression of reproductive genes, an increase in vitellogenin levels and histopathological lesions in the testes after EE2 exposure. Additionally, lipid peroxidation and changes in antioxidant enzyme activities were observed at both tested concentrations, along with morphological changes and increased mortality at the higher concentration. Even the environmentally relevant concentration of EE2 poses a danger to the aquatic organisms as it changes D. rerio's reproductive and health parameters, indicating toxicity at molecular, cell, tissue, and organism levels.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40103 - Fishery

Projekt

<a href="/cs/project/EF16_019%2F0000869" target="_blank" >EF16_019/0000869: Udržitelná produkce zdravých ryb v různých akvakulturních systémech - PROFISH</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Fish Biology

ISSN

1095-8649

e-ISSN

1095-8649

Svazek periodika

106

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

1831-1844

Kód UT WoS článku

001419038700001

EID výsledku v databázi Scopus

2-s2.0-85218828182