Improved Synthesis of Dinuclear [M(μ-X)(η5-Cp*)X]2 Precursors for Half-Sandwich Complexes (M=Rh or Ir; X=Br or I)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F25%3AN0000075" target="_blank" >RIV/00027162:_____/25:N0000075 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15310/25:73633966

Výsledek na webu

<a href="https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/open.202500026" target="_blank" >https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/open.202500026</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/open.202500026" target="_blank" >10.1002/open.202500026</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Improved Synthesis of Dinuclear [M(μ-X)(η5-Cp*)X]2 Precursors for Half-Sandwich Complexes (M=Rh or Ir; X=Br or I)

Popis výsledku v původním jazyce

The long-known dinuclear complexes of the general formula [M(μ-X)(η5-Cp*)X]2 (1–4; M=Rh or Ir, X=Br or I; HCp*= pentamethylcyclopentadiene) represent important intermediates for the preparation of biologically (e. g., anticancer or antimicrobial) and catalytically active half-sandwich rhodium(III) and iridium(III) complexes. Here we report the optimized rapid microwave-assisted syntheses of the mentioned dinuclear synthons 1–4. With respect to their following synthetic utilization, we examined their antiproliferative activity in the representative human cancer cell lines, where they did not show any relevant cytotoxicity. However, the iridium complexes 3 and 4 exhibited considerable catalytic activity in a model transfer hydrogenation of acetophenone using propan-2-ol as the hydrogen source. The obtained comprehensive data sets can be useful in the evaluation of the ligand effects in complexes prepared from 1–4 and used in e. g. Bioinorganic and catalytic applications.

Název v anglickém jazyce

Improved Synthesis of Dinuclear [M(μ-X)(η5-Cp*)X]2 Precursors for Half-Sandwich Complexes (M=Rh or Ir; X=Br or I)

Popis výsledku anglicky

The long-known dinuclear complexes of the general formula [M(μ-X)(η5-Cp*)X]2 (1–4; M=Rh or Ir, X=Br or I; HCp*= pentamethylcyclopentadiene) represent important intermediates for the preparation of biologically (e. g., anticancer or antimicrobial) and catalytically active half-sandwich rhodium(III) and iridium(III) complexes. Here we report the optimized rapid microwave-assisted syntheses of the mentioned dinuclear synthons 1–4. With respect to their following synthetic utilization, we examined their antiproliferative activity in the representative human cancer cell lines, where they did not show any relevant cytotoxicity. However, the iridium complexes 3 and 4 exhibited considerable catalytic activity in a model transfer hydrogenation of acetophenone using propan-2-ol as the hydrogen source. The obtained comprehensive data sets can be useful in the evaluation of the ligand effects in complexes prepared from 1–4 and used in e. g. Bioinorganic and catalytic applications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/NU22-08-00236" target="_blank" >NU22-08-00236: Preklinické studie neplatinových metaloléčiv v terapii rakoviny plic</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ChemistryOpen

ISSN

2191-1363

e-ISSN

2191-1363

Svazek periodika

14

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

6

Strana od-do

—

Kód UT WoS článku

001436284600001

EID výsledku v databázi Scopus

2-s2.0-85219155747