Tramadol efficacy in patients with postoperative pain in relation to CYP2D6 and MDR1 polymorphisms

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F12%3A12599" target="_blank" >RIV/00064165:_____/12:12599 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/12:12599 RIV/00064203:_____/12:7994

Výsledek na webu

<a href="http://dx.doi.org/10.4149/BLL_2012_036" target="_blank" >http://dx.doi.org/10.4149/BLL_2012_036</a>

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Tramadol efficacy in patients with postoperative pain in relation to CYP2D6 and MDR1 polymorphisms

Popis výsledku v původním jazyce

The aim of our study was to evaluate impact of CYP2D6 and MDR1 polymorphisms on the analgesic efficacy of tramadol in patients after a knee arthroscopy. Pharmacokinetics of tramadol and its metabolites is stereoselective and displays high interindividualvariability correlating with polymorphic CYP2D6 in the population. Available data provide controversial results regarding the analgesic efficacy of tramadol in subjects with different CYP2D6 genotypes. METHODS: Pain intensity was assessed using visual analogue scale at 2 and 24 hours after the knee arthroscopy in 156 patients. Polymorphisms CYP2D6*3,*4,*5,*6, and gene duplication and C3435T in MDR1 gene were analyzed by PCR - RFLP. Results: Mean VAS2h value in the whole study group was 44.0 +/- 16.5 mm. Mean pain difference, was lowest in the UM group and highest in the PM group. The pain difference varied significantly among the CYP2D6 subgroups (F = 4.29; p = 0.006) with significant differences between homEM vs hetEM, homEM vs PM, an

Název v anglickém jazyce

Tramadol efficacy in patients with postoperative pain in relation to CYP2D6 and MDR1 polymorphisms

Popis výsledku anglicky

The aim of our study was to evaluate impact of CYP2D6 and MDR1 polymorphisms on the analgesic efficacy of tramadol in patients after a knee arthroscopy. Pharmacokinetics of tramadol and its metabolites is stereoselective and displays high interindividualvariability correlating with polymorphic CYP2D6 in the population. Available data provide controversial results regarding the analgesic efficacy of tramadol in subjects with different CYP2D6 genotypes. METHODS: Pain intensity was assessed using visual analogue scale at 2 and 24 hours after the knee arthroscopy in 156 patients. Polymorphisms CYP2D6*3,*4,*5,*6, and gene duplication and C3435T in MDR1 gene were analyzed by PCR - RFLP. Results: Mean VAS2h value in the whole study group was 44.0 +/- 16.5 mm. Mean pain difference, was lowest in the UM group and highest in the PM group. The pain difference varied significantly among the CYP2D6 subgroups (F = 4.29; p = 0.006) with significant differences between homEM vs hetEM, homEM vs PM, an

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

—

Projekt

<a href="/cs/project/GP305%2F08%2FP069" target="_blank" >GP305/08/P069: Farmakogenetika analgetického účinku tramadolu při léčbě akutní bolesti.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bratislavské lekárske listy

ISSN

0006-9248

e-ISSN

—

Svazek periodika

113

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

4

Strana od-do

152-155

Kód UT WoS článku

000302385900005

EID výsledku v databázi Scopus

—