MTNR1B Genetic Variability Is Associated with Gestational Diabetes in Czech Women

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F14%3A10292388" target="_blank" >RIV/00064165:_____/14:10292388 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023761:_____/14:#0000481

Výsledek na webu

<a href="http://dx.doi.org/10.1155/2014/508923" target="_blank" >http://dx.doi.org/10.1155/2014/508923</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2014/508923" target="_blank" >10.1155/2014/508923</a>

Jazyk výsledku

angličtina

Název v původním jazyce

MTNR1B Genetic Variability Is Associated with Gestational Diabetes in Czech Women

Popis výsledku v původním jazyce

The gene MTNR1B encodes a receptor for melatonin. Melatonin receptors are expressed in human beta-cells, which implies that genetic variants might affect glucose tolerance. Meta-analysis confirmed that the rs10830963 shows the most robust association. The aim of the study was to assess the rs10830963 in Czech GDM patients and controls and to study relations between the SNP and biochemical as well as anthropometric characteristics. Our cohort consisted of 880 women; 458 were diagnosed with GDM, and 422 were normoglycemic controls without history of GDM. Despite similar BMI, the GDM group showed higher WHR, waist circumference, abdominal circumference, and total body fat content. The risk allele G was more frequent in the GDM group (38.3 versus 29.4% incontrols, OR 1.49 CI95% [1.22; 1.82]; P-OR = 0.0001). In spite of higher frequency, the G allele in the GDM group was not associated with any markers of glucose metabolism. In contrast, controls showed significant association of the allel

Název v anglickém jazyce

MTNR1B Genetic Variability Is Associated with Gestational Diabetes in Czech Women

Popis výsledku anglicky

The gene MTNR1B encodes a receptor for melatonin. Melatonin receptors are expressed in human beta-cells, which implies that genetic variants might affect glucose tolerance. Meta-analysis confirmed that the rs10830963 shows the most robust association. The aim of the study was to assess the rs10830963 in Czech GDM patients and controls and to study relations between the SNP and biochemical as well as anthropometric characteristics. Our cohort consisted of 880 women; 458 were diagnosed with GDM, and 422 were normoglycemic controls without history of GDM. Despite similar BMI, the GDM group showed higher WHR, waist circumference, abdominal circumference, and total body fat content. The risk allele G was more frequent in the GDM group (38.3 versus 29.4% incontrols, OR 1.49 CI95% [1.22; 1.82]; P-OR = 0.0001). In spite of higher frequency, the G allele in the GDM group was not associated with any markers of glucose metabolism. In contrast, controls showed significant association of the allel

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/NT13544" target="_blank" >NT13544: Role genetické variability v patogenezi diabetes mellitus 2. typu a gestačního diabetu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Endocrinology

ISSN

1687-8337

e-ISSN

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Svazek periodika

neuveden

Číslo periodika v rámci svazku

July

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

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Kód UT WoS článku

000339763300001

EID výsledku v databázi Scopus

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