Constitutive modeling of human saphenous veins at overloading pressures

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F15%3A10294995" target="_blank" >RIV/00064165:_____/15:10294995 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/15:43909419 RIV/68407700:21220/15:00227701 RIV/27283933:_____/15:N0000032 RIV/00064173:_____/15:N0000009

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jmbbm.2015.01.023" target="_blank" >http://dx.doi.org/10.1016/j.jmbbm.2015.01.023</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jmbbm.2015.01.023" target="_blank" >10.1016/j.jmbbm.2015.01.023</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Constitutive modeling of human saphenous veins at overloading pressures

Popis výsledku v původním jazyce

In the present study, inflation tests with free axial extension of 15 human vena saphena magna were conducted ex vivo to obtain data suitable for multi-axial constitutive modeling at overloading conditions (pressures up to approximately 15 kPa). Subsequently the data were fitted with a hyperelastic, nonlinear and anisotropic constitutive model based on the theory of the closed thick-walled tube. It was observed that initial highly deformable behavior (up to approximately 2.5 kPa) in the pressure-circumferential stretch response is followed by progressive large strain stiffening. Contrary to that, samples were much stiffer in longitudinal direction, where the observed stretches were in the range 0.98-1.03 during the entire pressurization in most cases. The effect of possible residual stress was evaluated in a simulation of the intramural stress distribution with the opening angle prescribed to 0 degrees, 10 degrees, 20 degrees, 30 degrees, 40 degrees, and 50 degrees. The result suggests that the optimal opening angle making the stress distribution through the wall thickness uniform is about 40 degrees. The material parameters presented here are suitable for use in mechanobiological simulations describing the adaptation of the autologous vein wall after bypass surgery.

Název v anglickém jazyce

Constitutive modeling of human saphenous veins at overloading pressures

Popis výsledku anglicky

In the present study, inflation tests with free axial extension of 15 human vena saphena magna were conducted ex vivo to obtain data suitable for multi-axial constitutive modeling at overloading conditions (pressures up to approximately 15 kPa). Subsequently the data were fitted with a hyperelastic, nonlinear and anisotropic constitutive model based on the theory of the closed thick-walled tube. It was observed that initial highly deformable behavior (up to approximately 2.5 kPa) in the pressure-circumferential stretch response is followed by progressive large strain stiffening. Contrary to that, samples were much stiffer in longitudinal direction, where the observed stretches were in the range 0.98-1.03 during the entire pressurization in most cases. The effect of possible residual stress was evaluated in a simulation of the intramural stress distribution with the opening angle prescribed to 0 degrees, 10 degrees, 20 degrees, 30 degrees, 40 degrees, and 50 degrees. The result suggests that the optimal opening angle making the stress distribution through the wall thickness uniform is about 40 degrees. The material parameters presented here are suitable for use in mechanobiological simulations describing the adaptation of the autologous vein wall after bypass surgery.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BO - Biofyzika

OECD FORD obor

—

Projekt

<a href="/cs/project/NT13302" target="_blank" >NT13302: Optimalizace fysikálních charakteristik cévních náhrad pro nízké průtoky</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the Mechanical Behavior of Biomedical Materials

ISSN

1751-6161

e-ISSN

—

Svazek periodika

45

Číslo periodika v rámci svazku

May

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

101-108

Kód UT WoS článku

000352665100010

EID výsledku v databázi Scopus

2-s2.0-84923043137