Comparison of MicroRNA Content in Plasma and Urine Indicates the Existence of a Transrenal Passage of Selected MicroRNAs

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10327076" target="_blank" >RIV/00064165:_____/16:10327076 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/16:10327076 RIV/00064203:_____/16:10327076 RIV/00216208:11110/16:10327076

Výsledek na webu

<a href="http://dx.doi.org/10.1007/978-3-319-42044-8_18" target="_blank" >http://dx.doi.org/10.1007/978-3-319-42044-8_18</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-319-42044-8_18" target="_blank" >10.1007/978-3-319-42044-8_18</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comparison of MicroRNA Content in Plasma and Urine Indicates the Existence of a Transrenal Passage of Selected MicroRNAs

Popis výsledku v původním jazyce

MicroRNAs (miRNAs) in urine are examined as potential biomarkers. We examined the urine samples from 70 individuals (45 males, 25 females, mean age 65 years, range 20-84 years). Of the urine donors, 15 were healthy volunteers, 5 were patients with non-cancer diseases, 50 were patients with different stages of bladder cancer. To examine the spectrum of miRNAs in the cell-free fraction of urine, TaqMan Human miRNA Array Card A v.2.1 was used. A set of 30 miRNAs were found that are constantly present in urine supernatants independently of sex, age and health status of the subjects. We compared this set with miRNAs found in plasma, expressed in kidney and genito-urinary tract. Our results indicate that some miRNA could be transferred from the circulation into urine.

Název v anglickém jazyce

Comparison of MicroRNA Content in Plasma and Urine Indicates the Existence of a Transrenal Passage of Selected MicroRNAs

Popis výsledku anglicky

MicroRNAs (miRNAs) in urine are examined as potential biomarkers. We examined the urine samples from 70 individuals (45 males, 25 females, mean age 65 years, range 20-84 years). Of the urine donors, 15 were healthy volunteers, 5 were patients with non-cancer diseases, 50 were patients with different stages of bladder cancer. To examine the spectrum of miRNAs in the cell-free fraction of urine, TaqMan Human miRNA Array Card A v.2.1 was used. A set of 30 miRNAs were found that are constantly present in urine supernatants independently of sex, age and health status of the subjects. We compared this set with miRNAs found in plasma, expressed in kidney and genito-urinary tract. Our results indicate that some miRNA could be transferred from the circulation into urine.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT12417" target="_blank" >NT12417: Využití mikroRNA, mRNA a volné DNA pro časnou neinvazivní detekci a stanovení prognózy u pacientů s karcinomem močového měchýře</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Advances in Experimental Medicine and Biology

ISSN

0065-2598

e-ISSN

—

Svazek periodika

924

Číslo periodika v rámci svazku

October

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

97-100

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-84996551493