Cold-stored arterial allografts for in situ reconstruction of infected prosthetic grafts. Review of immunosuppressive protocols used in clinical practice
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10327091" target="_blank" >RIV/00064165:_____/16:10327091 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11110/16:10327091
Výsledek na webu
<a href="http://dx.doi.org/10.1007/s10353-016-0401-9" target="_blank" >http://dx.doi.org/10.1007/s10353-016-0401-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10353-016-0401-9" target="_blank" >10.1007/s10353-016-0401-9</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Cold-stored arterial allografts for in situ reconstruction of infected prosthetic grafts. Review of immunosuppressive protocols used in clinical practice
Popis výsledku v původním jazyce
Introduction: Strong antigenicity of arterial allografts triggering immune response similar to rejection processes evident in solid organ transplant recipients was observed in animal experiments. A higher incidence of graft-related death, graft ruptures or thrombosis and graft aneurysm formation was observed in non-immunosuppressed patients after arterial implantation. Methodology: The use of immunosuppression is not generally accepted by vascular surgeons. In the cases in which immunosuppressive therapy is administered, the drug most frequently used is cyclosporine A (CyA). This therapy has shown good mid-term results with no signs of recurrent infection. New immunosuppressive protocols with tacrolimus or sirolimus were published recently. These drugs are routinely used in solid organ transplant patients and show some advantages, compared to cyclosporine A, with respect to hypertension, dyslipidaemia, and renal function. Results: The authors present available clinical immunosuppressive protocols in this indication and the results. Moreover, our group has published good experimental and clinical results with immunosuppressive protocol featuring the delayed use of tacrolimus after transplantation of cold-stored arterial allograft. Conclusion: All this long-term experience with immunosuppression suggests the hypothesis that this therapy has a place in the armamentarium of the vascular surgeon performing arterial allograft implantations.
Název v anglickém jazyce
Cold-stored arterial allografts for in situ reconstruction of infected prosthetic grafts. Review of immunosuppressive protocols used in clinical practice
Popis výsledku anglicky
Introduction: Strong antigenicity of arterial allografts triggering immune response similar to rejection processes evident in solid organ transplant recipients was observed in animal experiments. A higher incidence of graft-related death, graft ruptures or thrombosis and graft aneurysm formation was observed in non-immunosuppressed patients after arterial implantation. Methodology: The use of immunosuppression is not generally accepted by vascular surgeons. In the cases in which immunosuppressive therapy is administered, the drug most frequently used is cyclosporine A (CyA). This therapy has shown good mid-term results with no signs of recurrent infection. New immunosuppressive protocols with tacrolimus or sirolimus were published recently. These drugs are routinely used in solid organ transplant patients and show some advantages, compared to cyclosporine A, with respect to hypertension, dyslipidaemia, and renal function. Results: The authors present available clinical immunosuppressive protocols in this indication and the results. Moreover, our group has published good experimental and clinical results with immunosuppressive protocol featuring the delayed use of tacrolimus after transplantation of cold-stored arterial allograft. Conclusion: All this long-term experience with immunosuppression suggests the hypothesis that this therapy has a place in the armamentarium of the vascular surgeon performing arterial allograft implantations.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FJ - Chirurgie včetně transplantologie
OECD FORD obor
—
Návaznosti výsledku
Projekt
—
Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2016
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
European Surgery-Acta Chirurgica Austriaca
ISSN
1682-8631
e-ISSN
—
Svazek periodika
48
Číslo periodika v rámci svazku
Supplement 2
Stát vydavatele periodika
AT - Rakouská republika
Počet stran výsledku
3
Strana od-do
166-168
Kód UT WoS článku
000376594600014
EID výsledku v databázi Scopus
2-s2.0-84965026285