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Cold-stored arterial allografts for in situ reconstruction of infected prosthetic grafts. Review of immunosuppressive protocols used in clinical practice

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10327091" target="_blank" >RIV/00064165:_____/16:10327091 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00216208:11110/16:10327091

  • Výsledek na webu

    <a href="http://dx.doi.org/10.1007/s10353-016-0401-9" target="_blank" >http://dx.doi.org/10.1007/s10353-016-0401-9</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s10353-016-0401-9" target="_blank" >10.1007/s10353-016-0401-9</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Cold-stored arterial allografts for in situ reconstruction of infected prosthetic grafts. Review of immunosuppressive protocols used in clinical practice

  • Popis výsledku v původním jazyce

    Introduction: Strong antigenicity of arterial allografts triggering immune response similar to rejection processes evident in solid organ transplant recipients was observed in animal experiments. A higher incidence of graft-related death, graft ruptures or thrombosis and graft aneurysm formation was observed in non-immunosuppressed patients after arterial implantation. Methodology: The use of immunosuppression is not generally accepted by vascular surgeons. In the cases in which immunosuppressive therapy is administered, the drug most frequently used is cyclosporine A (CyA). This therapy has shown good mid-term results with no signs of recurrent infection. New immunosuppressive protocols with tacrolimus or sirolimus were published recently. These drugs are routinely used in solid organ transplant patients and show some advantages, compared to cyclosporine A, with respect to hypertension, dyslipidaemia, and renal function. Results: The authors present available clinical immunosuppressive protocols in this indication and the results. Moreover, our group has published good experimental and clinical results with immunosuppressive protocol featuring the delayed use of tacrolimus after transplantation of cold-stored arterial allograft. Conclusion: All this long-term experience with immunosuppression suggests the hypothesis that this therapy has a place in the armamentarium of the vascular surgeon performing arterial allograft implantations.

  • Název v anglickém jazyce

    Cold-stored arterial allografts for in situ reconstruction of infected prosthetic grafts. Review of immunosuppressive protocols used in clinical practice

  • Popis výsledku anglicky

    Introduction: Strong antigenicity of arterial allografts triggering immune response similar to rejection processes evident in solid organ transplant recipients was observed in animal experiments. A higher incidence of graft-related death, graft ruptures or thrombosis and graft aneurysm formation was observed in non-immunosuppressed patients after arterial implantation. Methodology: The use of immunosuppression is not generally accepted by vascular surgeons. In the cases in which immunosuppressive therapy is administered, the drug most frequently used is cyclosporine A (CyA). This therapy has shown good mid-term results with no signs of recurrent infection. New immunosuppressive protocols with tacrolimus or sirolimus were published recently. These drugs are routinely used in solid organ transplant patients and show some advantages, compared to cyclosporine A, with respect to hypertension, dyslipidaemia, and renal function. Results: The authors present available clinical immunosuppressive protocols in this indication and the results. Moreover, our group has published good experimental and clinical results with immunosuppressive protocol featuring the delayed use of tacrolimus after transplantation of cold-stored arterial allograft. Conclusion: All this long-term experience with immunosuppression suggests the hypothesis that this therapy has a place in the armamentarium of the vascular surgeon performing arterial allograft implantations.

Klasifikace

  • Druh

    J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

  • CEP obor

    FJ - Chirurgie včetně transplantologie

  • OECD FORD obor

Návaznosti výsledku

  • Projekt

  • Návaznosti

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Ostatní

  • Rok uplatnění

    2016

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    European Surgery-Acta Chirurgica Austriaca

  • ISSN

    1682-8631

  • e-ISSN

  • Svazek periodika

    48

  • Číslo periodika v rámci svazku

    Supplement 2

  • Stát vydavatele periodika

    AT - Rakouská republika

  • Počet stran výsledku

    3

  • Strana od-do

    166-168

  • Kód UT WoS článku

    000376594600014

  • EID výsledku v databázi Scopus

    2-s2.0-84965026285