Cystatin C is associated with the extent and characteristics of coronary atherosclerosis in patients with preserved renal function

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10330651" target="_blank" >RIV/00064165:_____/16:10330651 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/16:10330651 RIV/00023884:_____/16:00007717

Výsledek na webu

<a href="http://fb.cuni.cz/file/5824/fb2016a0028.pdf" target="_blank" >http://fb.cuni.cz/file/5824/fb2016a0028.pdf</a>

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Cystatin C is associated with the extent and characteristics of coronary atherosclerosis in patients with preserved renal function

Popis výsledku v původním jazyce

Cystatin C (CysC), an endogenous inhibitor of cysteine proteases and a sensitive and accurate marker of renal function, is associated with the severity of coronary atherosclerosis assessed by angiography and future cardiovascular events according to previous studies. We aimed to evaluate the association between CysC levels and coronary plaque volume, composition and phenotype assessed by intravascular ultrasound and intravascular ultrasound-derived virtual histology in patients with preserved renal function. Forty-four patients with angiographically documented coronary artery disease and complete intravascular imaging were included in the study. Patients were categorized into tertiles by CysC levels. Subjects in the high CysC tertile had significantly higher mean plaque burden (48.0 % +- 6.9 vs. 42.8 % +- 7.4, P = 0.029), lower mean lumen area (8.1 mm2 +- 1.7 vs. 9.9 mm2 +- 3.1, P = 0.044) and a higher number of 5-mm vessel segments with minimum lumen area < 4 mm2 (17.9 +- 18.9 vs. 6.8 +- 11.7, P = 0.021) compared to patients in the lower tertiles. In addition, CysC levels demonstrated significant positive correlation with the mean plaque burden (r = 0.35, P = 0.021). Neither relative, nor absolute plaque components differed significantly according to CysC tertiles. The Liverpool Active Plaque Score was significantly higher in the high CysC tertile patients (0.91 +- 1.0 vs. 0.18 +- 0.92, P = 0.02). In conclusion, our study demonstrated a significant association of increased CysC levels with more advanced coronary artery disease and higher risk plaque phenotype in patients with preserved renal function.

Název v anglickém jazyce

Cystatin C is associated with the extent and characteristics of coronary atherosclerosis in patients with preserved renal function

Popis výsledku anglicky

Cystatin C (CysC), an endogenous inhibitor of cysteine proteases and a sensitive and accurate marker of renal function, is associated with the severity of coronary atherosclerosis assessed by angiography and future cardiovascular events according to previous studies. We aimed to evaluate the association between CysC levels and coronary plaque volume, composition and phenotype assessed by intravascular ultrasound and intravascular ultrasound-derived virtual histology in patients with preserved renal function. Forty-four patients with angiographically documented coronary artery disease and complete intravascular imaging were included in the study. Patients were categorized into tertiles by CysC levels. Subjects in the high CysC tertile had significantly higher mean plaque burden (48.0 % +- 6.9 vs. 42.8 % +- 7.4, P = 0.029), lower mean lumen area (8.1 mm2 +- 1.7 vs. 9.9 mm2 +- 3.1, P = 0.044) and a higher number of 5-mm vessel segments with minimum lumen area < 4 mm2 (17.9 +- 18.9 vs. 6.8 +- 11.7, P = 0.021) compared to patients in the lower tertiles. In addition, CysC levels demonstrated significant positive correlation with the mean plaque burden (r = 0.35, P = 0.021). Neither relative, nor absolute plaque components differed significantly according to CysC tertiles. The Liverpool Active Plaque Score was significantly higher in the high CysC tertile patients (0.91 +- 1.0 vs. 0.18 +- 0.92, P = 0.02). In conclusion, our study demonstrated a significant association of increased CysC levels with more advanced coronary artery disease and higher risk plaque phenotype in patients with preserved renal function.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

<a href="/cs/project/LH12053" target="_blank" >LH12053: Predikce rozsahu a rizikovosti koronárního postižení a jejich změn při hypolipidemické terapii na základě neinvazivních vyšetření</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Folia Biologica

ISSN

0015-5500

e-ISSN

—

Svazek periodika

62

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

10

Strana od-do

225-234

Kód UT WoS článku

000398215600001

EID výsledku v databázi Scopus

2-s2.0-85013335423