Statin non-adherence and residual cardiovascular risk: There is need for substantial improvement

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10330797" target="_blank" >RIV/00064165:_____/16:10330797 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/16:10330797

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.ijcard.2016.09.075" target="_blank" >http://dx.doi.org/10.1016/j.ijcard.2016.09.075</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijcard.2016.09.075" target="_blank" >10.1016/j.ijcard.2016.09.075</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Statin non-adherence and residual cardiovascular risk: There is need for substantial improvement

Popis výsledku v původním jazyce

Although statin therapy has proven to be the cornerstone for prevention and treatment of cardiovascular disease (CVD), there are many patients for whom long-term therapy remains suboptimal. The aims of this article are to review the current complex issues associated with statin use and to explore when novel treatment approaches should be considered. Statin discontinuation as well as adherence to statin therapy remain two of the greatest challenges for lipidologists. Evidence suggests that between 40 and 75% of patients discontinue their statin therapy within one year after initiation. Furthermore, whilst the reasons for persistence with statin therapy are complex, evidence shows that low-adherence to statins negatively impacts clinical outcomes and residual CV risk remains a major concern. Non-adherence or lack of persistence with long-term statin therapy in real-lifemay be the main cause of inadequate lowdensity lipoprotein cholesterol loweringwith statins. There is a large need for the improvement of the use of statins,which have good safety profiles and are inexpensive. On the other hand, in a non-cost-constrained environment, proprotein convertase subtilisin/kexin type 9 inhibitors should arguably be used more often in those patients in whom treatment with statins remains unsatisfactory.

Název v anglickém jazyce

Statin non-adherence and residual cardiovascular risk: There is need for substantial improvement

Popis výsledku anglicky

Although statin therapy has proven to be the cornerstone for prevention and treatment of cardiovascular disease (CVD), there are many patients for whom long-term therapy remains suboptimal. The aims of this article are to review the current complex issues associated with statin use and to explore when novel treatment approaches should be considered. Statin discontinuation as well as adherence to statin therapy remain two of the greatest challenges for lipidologists. Evidence suggests that between 40 and 75% of patients discontinue their statin therapy within one year after initiation. Furthermore, whilst the reasons for persistence with statin therapy are complex, evidence shows that low-adherence to statins negatively impacts clinical outcomes and residual CV risk remains a major concern. Non-adherence or lack of persistence with long-term statin therapy in real-lifemay be the main cause of inadequate lowdensity lipoprotein cholesterol loweringwith statins. There is a large need for the improvement of the use of statins,which have good safety profiles and are inexpensive. On the other hand, in a non-cost-constrained environment, proprotein convertase subtilisin/kexin type 9 inhibitors should arguably be used more often in those patients in whom treatment with statins remains unsatisfactory.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Cardiology

ISSN

0167-5273

e-ISSN

—

Svazek periodika

225

Číslo periodika v rámci svazku

December

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

13

Strana od-do

184-196

Kód UT WoS článku

000390472000042

EID výsledku v databázi Scopus

2-s2.0-84990196360