Complete diagnostics and clinical approach for a female patient with unusual glioblastoma: A case study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10331429" target="_blank" >RIV/00064165:_____/16:10331429 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/16:10331429 RIV/00216208:11130/16:10331429 RIV/00216208:11140/16:10331429 RIV/00216208:11120/16:43911788 RIV/00064173:_____/16:N0000236

Výsledek na webu

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906621/pdf/mco-05-01-0161.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906621/pdf/mco-05-01-0161.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3892/mco.2016.891" target="_blank" >10.3892/mco.2016.891</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Complete diagnostics and clinical approach for a female patient with unusual glioblastoma: A case study

Popis výsledku v původním jazyce

The present study reports a case of a 44-year-old female patient with a large frontal lobe tumor who underwent surgery using a modern navigation system SonoWand that combines the advantages of a non-frame navigation system with intraoperative real-time ultrasound imaging. The right frontal lobe tumor consisted of two morphologically different sections. A diffuse astrocytoma grade II and a glioblastoma grade IV were identified. These tumors were relatively substantially separated. A 17 p deletion, including TP53, was detected in a diffuse astrocytoma but not in a glioblastoma. EGFR and MDM2 amplifications were detected only in a glioblastoma. Detection of these amplifications is typical for primary glioblastomas. These findings support our assumption of two independent tumors. The KRAS, BRAF and EGFR gene mutations were also detected in a glioblastoma. Such an accumulation of molecular mutations is rare in one tumor. Following oncological treatment the patient was cared for in the oncological center and survived for 15 months after the surgery without any signs of a disease. This is an unusual case, and to the best of our knowledge, is not frequently published in literature.

Název v anglickém jazyce

Complete diagnostics and clinical approach for a female patient with unusual glioblastoma: A case study

Popis výsledku anglicky

The present study reports a case of a 44-year-old female patient with a large frontal lobe tumor who underwent surgery using a modern navigation system SonoWand that combines the advantages of a non-frame navigation system with intraoperative real-time ultrasound imaging. The right frontal lobe tumor consisted of two morphologically different sections. A diffuse astrocytoma grade II and a glioblastoma grade IV were identified. These tumors were relatively substantially separated. A 17 p deletion, including TP53, was detected in a diffuse astrocytoma but not in a glioblastoma. EGFR and MDM2 amplifications were detected only in a glioblastoma. Detection of these amplifications is typical for primary glioblastomas. These findings support our assumption of two independent tumors. The KRAS, BRAF and EGFR gene mutations were also detected in a glioblastoma. Such an accumulation of molecular mutations is rare in one tumor. Following oncological treatment the patient was cared for in the oncological center and survived for 15 months after the surgery without any signs of a disease. This is an unusual case, and to the best of our knowledge, is not frequently published in literature.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecular and Clinical Oncology

ISSN

2049-9450

e-ISSN

—

Svazek periodika

5

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GR - Řecká republika

Počet stran výsledku

4

Strana od-do

161-164

Kód UT WoS článku

000453166300038

EID výsledku v databázi Scopus

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