Risk factors for progression in children and young adults with IgA nephropathy: an analysis of 261 cases from the VALIGA European cohort

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F17%3A10361547" target="_blank" >RIV/00064165:_____/17:10361547 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00467-016-3469-3" target="_blank" >http://dx.doi.org/10.1007/s00467-016-3469-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00467-016-3469-3" target="_blank" >10.1007/s00467-016-3469-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Risk factors for progression in children and young adults with IgA nephropathy: an analysis of 261 cases from the VALIGA European cohort

Popis výsledku v původním jazyce

There is a need for early identification of children with immunoglobulin A nephropathy (IgAN) at risk of progression of kidney disease. Data on 261 young patients [age &lt; 23 years; mean follow-up of 4.9 (range 2.5-8.1) years] enrolled in VALIGA, a study designed to validate the Oxford Classification of IgAN, were assessed. Renal biopsies were scored for the presence of mesangial hypercellularity (M1), endocapillary hypercellularity (E1), segmental glomerulosclerosis (S1), tubular atrophy/interstitial fibrosis (T1-2) (MEST score) and crescents (C1). Progression was assessed as end stage renal disease and/or a 50 % loss of estimated glomerular filtration rate (eGFR) (combined endpoint) as well as the rate of renal function decline (slope of eGFR). Cox regression and tree classification binary models were used and compared. In this cohort of 261 subjects aged &lt; 23 years, Cox analysis validated the MEST M, S and T scores for predicting survival to the combined endpoint but failed to prove that these scores had predictive value in the sub-group of 174 children aged &lt; 18 years. The regression tree classification indicated that patients with M1 were at risk of developing higher time-averaged proteinuria (p &lt; 0.0001) and the combined endpoint (p &lt; 0.001). An initial proteinuria of ae&lt;yen&gt;0.4 g/day/1.73 m(2) and an eGFR of &lt; 90 ml/min/1.73 m(2) were determined to be risk factors in subjects with M0. Children aged &lt; 16 years with M0 and well-preserved eGFR (&gt; 90 ml/min/1.73 m(2)) at presentation had a significantly high probability of proteinuria remission during follow-up and a higher remission rate following treatment with corticosteroid and/or immunosuppressive therapy. This new statistical approach has identified clinical and histological risk factors associated with outcome in children and young adults with IgAN.

Název v anglickém jazyce

Risk factors for progression in children and young adults with IgA nephropathy: an analysis of 261 cases from the VALIGA European cohort

Popis výsledku anglicky

There is a need for early identification of children with immunoglobulin A nephropathy (IgAN) at risk of progression of kidney disease. Data on 261 young patients [age &lt; 23 years; mean follow-up of 4.9 (range 2.5-8.1) years] enrolled in VALIGA, a study designed to validate the Oxford Classification of IgAN, were assessed. Renal biopsies were scored for the presence of mesangial hypercellularity (M1), endocapillary hypercellularity (E1), segmental glomerulosclerosis (S1), tubular atrophy/interstitial fibrosis (T1-2) (MEST score) and crescents (C1). Progression was assessed as end stage renal disease and/or a 50 % loss of estimated glomerular filtration rate (eGFR) (combined endpoint) as well as the rate of renal function decline (slope of eGFR). Cox regression and tree classification binary models were used and compared. In this cohort of 261 subjects aged &lt; 23 years, Cox analysis validated the MEST M, S and T scores for predicting survival to the combined endpoint but failed to prove that these scores had predictive value in the sub-group of 174 children aged &lt; 18 years. The regression tree classification indicated that patients with M1 were at risk of developing higher time-averaged proteinuria (p &lt; 0.0001) and the combined endpoint (p &lt; 0.001). An initial proteinuria of ae&lt;yen&gt;0.4 g/day/1.73 m(2) and an eGFR of &lt; 90 ml/min/1.73 m(2) were determined to be risk factors in subjects with M0. Children aged &lt; 16 years with M0 and well-preserved eGFR (&gt; 90 ml/min/1.73 m(2)) at presentation had a significantly high probability of proteinuria remission during follow-up and a higher remission rate following treatment with corticosteroid and/or immunosuppressive therapy. This new statistical approach has identified clinical and histological risk factors associated with outcome in children and young adults with IgAN.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30217 - Urology and nephrology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pediatric Nephrology

ISSN

0931-041X

e-ISSN

—

Svazek periodika

32

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

139-150

Kód UT WoS článku

000388976400016

EID výsledku v databázi Scopus

2-s2.0-84983465950