Mitochondrial Dysfunctions in Bipolar Disorder: Effect of the Disease and Pharmacotherapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F17%3A10361785" target="_blank" >RIV/00064165:_____/17:10361785 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/17:10361785

Výsledek na webu

<a href="http://dx.doi.org/10.2174/1871527315666161213110518" target="_blank" >http://dx.doi.org/10.2174/1871527315666161213110518</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1871527315666161213110518" target="_blank" >10.2174/1871527315666161213110518</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mitochondrial Dysfunctions in Bipolar Disorder: Effect of the Disease and Pharmacotherapy

Popis výsledku v původním jazyce

Exact pathophysiological mechanisms of bipolar disorder have not been sufficiently clarified. We review the evidence of mitochondrial dysfunctions on the relation between both disease and pharmacotherapy. Mitochondria produce the most of energy-rich molecules of adenosine triphosphate (ATP), apart from energy production they are involved in other functions: regulation of free radicals, antioxidant defenses, lipid peroxidation, calcium metabolism and participate in the intrinsic pathway of apoptosis. According to increasing evidence dysfunctions of mitochondria are associated with affective disorders, a hypothesis of impaired mitochondrial functions has been proposed in bipolar disorder pathogenesis. Mitochondrial DNA mutations and/or polymorphisms, impaired phospholipid metabolism and glycolytic shift, decrease in ATP production, increased oxidative stress and changes of intracellular calcium are concerned in mood disorders and effects of mood stabilizers. Recent studies have also provided data about the positive effects of chronic treatment by mood stabilizers on mitochondrial functions.

Název v anglickém jazyce

Mitochondrial Dysfunctions in Bipolar Disorder: Effect of the Disease and Pharmacotherapy

Popis výsledku anglicky

Exact pathophysiological mechanisms of bipolar disorder have not been sufficiently clarified. We review the evidence of mitochondrial dysfunctions on the relation between both disease and pharmacotherapy. Mitochondria produce the most of energy-rich molecules of adenosine triphosphate (ATP), apart from energy production they are involved in other functions: regulation of free radicals, antioxidant defenses, lipid peroxidation, calcium metabolism and participate in the intrinsic pathway of apoptosis. According to increasing evidence dysfunctions of mitochondria are associated with affective disorders, a hypothesis of impaired mitochondrial functions has been proposed in bipolar disorder pathogenesis. Mitochondrial DNA mutations and/or polymorphisms, impaired phospholipid metabolism and glycolytic shift, decrease in ATP production, increased oxidative stress and changes of intracellular calcium are concerned in mood disorders and effects of mood stabilizers. Recent studies have also provided data about the positive effects of chronic treatment by mood stabilizers on mitochondrial functions.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/NV15-28616A" target="_blank" >NV15-28616A: Mitochondriální dysfunkce při bipolární afektivní poruše</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CNS &amp; Neurological Disorders - Drug Targets

ISSN

1871-5273

e-ISSN

—

Svazek periodika

16

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

176-186

Kód UT WoS článku

000399558900010

EID výsledku v databázi Scopus

2-s2.0-85015687273