Mitochondrial Dysfunction in Blood Platelets of Patients with Manic Episode of Bipolar Disorder

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10385725" target="_blank" >RIV/00064165:_____/19:10385725 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/19:10385725

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=bX~eMYrH-w" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=bX~eMYrH-w</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1871527318666181224130011" target="_blank" >10.2174/1871527318666181224130011</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mitochondrial Dysfunction in Blood Platelets of Patients with Manic Episode of Bipolar Disorder

Popis výsledku v původním jazyce

We measured selected mitochondrial parameters in peripheral blood components. The analyses were performed for patients suffering from a manic episode and during remission and were compared to those performed for healthy controls. Mitochondrial respiration was examined in intact and permeabilized blood platelets using high-resolution respirometry. The citrate synthase (CS) and electron transport system (ETS) complex (complex I, II, and IV) activities were examined in platelets. The CS, complex II and complex IV activities were decreased in the BAD patients, complex I activity was increased, and the ratio of complex I to CS was significantly increased. In the intact platelets, respiration after complex I inhibition and residual oxygen consumption were decreased in the BAD patients compared to the healthy controls. In the permeabilized platelets, a decreased ETS capacity was found in the BAD patients. No significant differences were found between BAD patients in mania and remission. Increased complex I activity can be a compensatory mechanism for decreased CS and complex II and IV activities. We conclude that complex I and its abnormal activity contribute to defects in cellular energy metabolism during a manic episode and that the deficiency in the complex&apos;s functioning, but not the availability of oxidative phosphorylation substrates, seems to be responsible for the decreased ETS capacity in BAD patients. The observed parameters can be further evaluated as &apos;trait&apos; markers of BAD

Název v anglickém jazyce

Mitochondrial Dysfunction in Blood Platelets of Patients with Manic Episode of Bipolar Disorder

Popis výsledku anglicky

We measured selected mitochondrial parameters in peripheral blood components. The analyses were performed for patients suffering from a manic episode and during remission and were compared to those performed for healthy controls. Mitochondrial respiration was examined in intact and permeabilized blood platelets using high-resolution respirometry. The citrate synthase (CS) and electron transport system (ETS) complex (complex I, II, and IV) activities were examined in platelets. The CS, complex II and complex IV activities were decreased in the BAD patients, complex I activity was increased, and the ratio of complex I to CS was significantly increased. In the intact platelets, respiration after complex I inhibition and residual oxygen consumption were decreased in the BAD patients compared to the healthy controls. In the permeabilized platelets, a decreased ETS capacity was found in the BAD patients. No significant differences were found between BAD patients in mania and remission. Increased complex I activity can be a compensatory mechanism for decreased CS and complex II and IV activities. We conclude that complex I and its abnormal activity contribute to defects in cellular energy metabolism during a manic episode and that the deficiency in the complex&apos;s functioning, but not the availability of oxidative phosphorylation substrates, seems to be responsible for the decreased ETS capacity in BAD patients. The observed parameters can be further evaluated as &apos;trait&apos; markers of BAD

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30215 - Psychiatry

Projekt

<a href="/cs/project/NV15-28616A" target="_blank" >NV15-28616A: Mitochondriální dysfunkce při bipolární afektivní poruše</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CNS &amp; Neurological Disorders - Drug Targets

ISSN

1871-5273

e-ISSN

—

Svazek periodika

18

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

222-231

Kód UT WoS článku

000466102200005

EID výsledku v databázi Scopus

2-s2.0-85065585115