Brain volumetric correlates of dysarthria in multiple sclerosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10395482" target="_blank" >RIV/00064165:_____/19:10395482 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21230/19:00331970 RIV/00216208:11110/19:10395482

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=SIf7pgc_CT" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=SIf7pgc_CT</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bandl.2019.04.009" target="_blank" >10.1016/j.bandl.2019.04.009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Brain volumetric correlates of dysarthria in multiple sclerosis

Popis výsledku v původním jazyce

Although dysarthria is a common pattern in multiple sclerosis (MS), the contribution of specific brain areas to key factors of dysarthria remains unknown. Speech data were acquired from 123 MS patients with Expanded Disability Status Scale (EDSS) ranging from 1 to 6.5 and 60 matched healthy controls. Results of computerized acoustic analyses of subtests on spastic and ataxic aspects of dysarthria were correlated with MRI-based brain volume measurements. Slow articulation rate during reading was associated with bilateral white and grey matter loss whereas reduced maximum speed during oral diadochokinesis was related to greater cerebellar involvement. Articulation rate showed similar correlation to whole brain atrophy (r = 0.46, p &lt; 0.001) as the standard clinical scales such as EDSS (r = -0.45, p &lt; 0.001). Our results support the critical role of the pyramidal tract and cerebellum in the modification of motor speech timing in MS.

Název v anglickém jazyce

Brain volumetric correlates of dysarthria in multiple sclerosis

Popis výsledku anglicky

Although dysarthria is a common pattern in multiple sclerosis (MS), the contribution of specific brain areas to key factors of dysarthria remains unknown. Speech data were acquired from 123 MS patients with Expanded Disability Status Scale (EDSS) ranging from 1 to 6.5 and 60 matched healthy controls. Results of computerized acoustic analyses of subtests on spastic and ataxic aspects of dysarthria were correlated with MRI-based brain volume measurements. Slow articulation rate during reading was associated with bilateral white and grey matter loss whereas reduced maximum speed during oral diadochokinesis was related to greater cerebellar involvement. Articulation rate showed similar correlation to whole brain atrophy (r = 0.46, p &lt; 0.001) as the standard clinical scales such as EDSS (r = -0.45, p &lt; 0.001). Our results support the critical role of the pyramidal tract and cerebellum in the modification of motor speech timing in MS.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/GA16-03322S" target="_blank" >GA16-03322S: Objasnění mechanismů rozvoje poruch řeči a hlasu u roztroušené sklerózy s využitím nových metod objektivní akustické analýzy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Brain and Language

ISSN

0093-934X

e-ISSN

—

Svazek periodika

194

Číslo periodika v rámci svazku

July

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

58-64

Kód UT WoS článku

000471735900006

EID výsledku v databázi Scopus

2-s2.0-85065553460