The left atrial substrate plays a significant role in the development of complex atrial tachycardia in patients with precapillary pulmonary hypertension

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10395674" target="_blank" >RIV/00064165:_____/19:10395674 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/19:10395674

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=PW01dAI_GE" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=PW01dAI_GE</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12872-019-1142-z" target="_blank" >10.1186/s12872-019-1142-z</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The left atrial substrate plays a significant role in the development of complex atrial tachycardia in patients with precapillary pulmonary hypertension

Popis výsledku v původním jazyce

Background: Atrial fibrillation (AF) and related atrial tachyarrhythmias (AT), including type I atrial flutter (AFL) are frequently observed in patients with pulmonary hypertension (PH). Their relationship to hemodynamic changes, atrial size, and ventricular function are still not fully verified. Methods: We retrospectively studied hemodynamic data, echocardiographic findings and arrhythmia incidence in 814 patients with invasively diagnosed precapillary PH (aged 59 +- 14 years; 46% males). Patients with combined or post-capillary PH were excluded. Results: AF / AT were identified in 225 (28%) of all the study population. Compared to the subgroup without arrhythmia, patients with AF / AT had elevated right atrial pressure (11 +- 5 vs. 9 +- 5 mmHg), wedge pressure (11 +- 3 vs. 10 +- 3), a more enlarged right atrium (50 +- 12 vs. 47 +- 11 mm) and an increased left atrial diameter in the parasternal long axis projection, p &lt; 0.05 for all comparisons. In the multivariate model, the left atrial size, patient age, arterial hypertension, diabetes and type of PH were associated with AF / AT occurrence, p &lt; 0.05. Patients with type I AFL were more frequently male (39 (80%) vs. 62 (42%)), were younger (61 +- 11 vs. 67 +- 10 years), had increased pulmonary artery mean pressure (50 +- 12 vs. 45 +- 12 mmHg), less advanced left atrial dilatation (38 +- 10 vs. 42 +- 7 mm), and a more enlarged right atrium (56 +- 12 vs. 48 +- 11) as compared to subjects with AF or other AT, p &lt; 0.05. Conclusions: The evidence of elevated wedge pressure and the enlargement of the left atrium especially in patients with AF suggest a parallel involvement of the left atrial substrate in arrhythmia formation despite invasively confirmed evidence of purely isolated precapillary PH. Substantial differences were noticed between patients with type I AFL and the remaining patients with other arrhythmia types.

Název v anglickém jazyce

The left atrial substrate plays a significant role in the development of complex atrial tachycardia in patients with precapillary pulmonary hypertension

Popis výsledku anglicky

Background: Atrial fibrillation (AF) and related atrial tachyarrhythmias (AT), including type I atrial flutter (AFL) are frequently observed in patients with pulmonary hypertension (PH). Their relationship to hemodynamic changes, atrial size, and ventricular function are still not fully verified. Methods: We retrospectively studied hemodynamic data, echocardiographic findings and arrhythmia incidence in 814 patients with invasively diagnosed precapillary PH (aged 59 +- 14 years; 46% males). Patients with combined or post-capillary PH were excluded. Results: AF / AT were identified in 225 (28%) of all the study population. Compared to the subgroup without arrhythmia, patients with AF / AT had elevated right atrial pressure (11 +- 5 vs. 9 +- 5 mmHg), wedge pressure (11 +- 3 vs. 10 +- 3), a more enlarged right atrium (50 +- 12 vs. 47 +- 11 mm) and an increased left atrial diameter in the parasternal long axis projection, p &lt; 0.05 for all comparisons. In the multivariate model, the left atrial size, patient age, arterial hypertension, diabetes and type of PH were associated with AF / AT occurrence, p &lt; 0.05. Patients with type I AFL were more frequently male (39 (80%) vs. 62 (42%)), were younger (61 +- 11 vs. 67 +- 10 years), had increased pulmonary artery mean pressure (50 +- 12 vs. 45 +- 12 mmHg), less advanced left atrial dilatation (38 +- 10 vs. 42 +- 7 mm), and a more enlarged right atrium (56 +- 12 vs. 48 +- 11) as compared to subjects with AF or other AT, p &lt; 0.05. Conclusions: The evidence of elevated wedge pressure and the enlargement of the left atrium especially in patients with AF suggest a parallel involvement of the left atrial substrate in arrhythmia formation despite invasively confirmed evidence of purely isolated precapillary PH. Substantial differences were noticed between patients with type I AFL and the remaining patients with other arrhythmia types.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

<a href="/cs/project/NV18-02-00027" target="_blank" >NV18-02-00027: Katetrizační ablace fibrilace síní a síňových tachykardií u nemocných s plicní hypertenzí: randomizovaná studie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BMC Cardiovascular Disorders

ISSN

1471-2261

e-ISSN

—

Svazek periodika

19

Číslo periodika v rámci svazku

June

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

157

Kód UT WoS článku

000473135200001

EID výsledku v databázi Scopus

2-s2.0-85068118427