Treatment of Wilson's disease - an update

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10395744" target="_blank" >RIV/00064165:_____/19:10395744 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/19:10395744

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=D7h5twJV1D" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=D7h5twJV1D</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/21678707.2019.1638248" target="_blank" >10.1080/21678707.2019.1638248</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Treatment of Wilson's disease - an update

Popis výsledku v původním jazyce

Introduction: Wilson&apos;s disease (WD) is one of the few genetic disorders that can be successfully treated if diagnosed early and treated correctly. Currently, two groups of drugs are used in WD treatment: chelators or zinc salts. Both treatments lead to negative copper body balance, reversing the pathological accumulation of copper in tissues, and removing excess copper from the body. Liver transplantation is established as a treatment option in the case of acute liver failure or progressive liver disease resistant to treatment. However, due to the large number of adverse drug reactions, the need for long-life treatment and the persistence of symptoms, there is a need for new, more effective and safer therapies to alleviate WD symptoms. Areas covered: This article discusses available treatment recommendations (anticopper and liver transplantation) and reviews the possibilities of symptomatic WD treatment as well as available research regarding future WD treatments. Expert opinion: Existing recommendations concerning WD treatment as well as liver transplantation are consistent and up-to-date, irrespective of the progress made in the search for new treatment modalities. Additionally, several case reports, series reports, and reviews encourage the symptomatic treatment of WD clinical symptoms, taking into account their severity and impact on quality of life.

Název v anglickém jazyce

Treatment of Wilson's disease - an update

Popis výsledku anglicky

Introduction: Wilson&apos;s disease (WD) is one of the few genetic disorders that can be successfully treated if diagnosed early and treated correctly. Currently, two groups of drugs are used in WD treatment: chelators or zinc salts. Both treatments lead to negative copper body balance, reversing the pathological accumulation of copper in tissues, and removing excess copper from the body. Liver transplantation is established as a treatment option in the case of acute liver failure or progressive liver disease resistant to treatment. However, due to the large number of adverse drug reactions, the need for long-life treatment and the persistence of symptoms, there is a need for new, more effective and safer therapies to alleviate WD symptoms. Areas covered: This article discusses available treatment recommendations (anticopper and liver transplantation) and reviews the possibilities of symptomatic WD treatment as well as available research regarding future WD treatments. Expert opinion: Existing recommendations concerning WD treatment as well as liver transplantation are consistent and up-to-date, irrespective of the progress made in the search for new treatment modalities. Additionally, several case reports, series reports, and reviews encourage the symptomatic treatment of WD clinical symptoms, taking into account their severity and impact on quality of life.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Expert Opinion on Orphan Drugs

ISSN

2167-8707

e-ISSN

—

Svazek periodika

7

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

287-294

Kód UT WoS článku

000473988200001

EID výsledku v databázi Scopus

2-s2.0-85069535424