Severity of asphyxia is a covariate of phenobarbital clearance in newborns undergoing hypothermia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10397517" target="_blank" >RIV/00064165:_____/19:10397517 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/19:10397517

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=RCX.RNDNMM" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=RCX.RNDNMM</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/14767058.2018.1432039" target="_blank" >10.1080/14767058.2018.1432039</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Severity of asphyxia is a covariate of phenobarbital clearance in newborns undergoing hypothermia

Popis výsledku v původním jazyce

Aim: Phenobarbital (PB) pharmacokinetics (PK) in asphyxiated newborns show large variability, not only explained by hypothermia (HT). We evaluated potential relevant covariates of PK of PB in newborns treated with or without HT for hypoxic-ischemic encephalopathy (HIE). Methods: Clearance (CL), distribution volume (Vd) and elimination half-life (t(1/2)) were calculated using one-compartment analysis. Covariates were clinical characteristics (weight, gestational age, hepatic, renal, and circulatory status), comedication and HIE severity [time to reach normal aEEG pattern (T(norm)aEEG), dichotomous, within 24 h] and asphyxia severity [severe aspyhxia = pH &lt;= 7.1 + Apgar score &lt;= 5 (5 min), dichotomous]. Student&apos;s t-test, two-way ANOVA, correlation and Pearson&apos;s chi-square test were used. Results: Forty newborns were included [14 non-HT; 26 HT with T(norm)aEEG &lt;24 h in 14/26 (group(1-HT)) and T(norm)aEEG &gt;= 24 h in 12/26 (group(2-HT))]. Severe asphyxia was present in 26/40 [5/14 non-HT, 11/14 and 10/12 in both HT groups]. PB-CL, Vd and t(1/2) were similar between the non-HT and HT group. However, within the HT group, PB-CL was significantly different between group(1-HT) and group(2-HT) (p = .043). ANOVA showed that HT (p = .034) and severity of asphyxia (p = .038) reduced PB-CL (-50%). Conclusion: The interaction of severity of asphyxia and HT is associated with a clinical relevant reduced PB-CL, suggesting the potential relevance of disease characteristics beyond HT itself.

Název v anglickém jazyce

Severity of asphyxia is a covariate of phenobarbital clearance in newborns undergoing hypothermia

Popis výsledku anglicky

Aim: Phenobarbital (PB) pharmacokinetics (PK) in asphyxiated newborns show large variability, not only explained by hypothermia (HT). We evaluated potential relevant covariates of PK of PB in newborns treated with or without HT for hypoxic-ischemic encephalopathy (HIE). Methods: Clearance (CL), distribution volume (Vd) and elimination half-life (t(1/2)) were calculated using one-compartment analysis. Covariates were clinical characteristics (weight, gestational age, hepatic, renal, and circulatory status), comedication and HIE severity [time to reach normal aEEG pattern (T(norm)aEEG), dichotomous, within 24 h] and asphyxia severity [severe aspyhxia = pH &lt;= 7.1 + Apgar score &lt;= 5 (5 min), dichotomous]. Student&apos;s t-test, two-way ANOVA, correlation and Pearson&apos;s chi-square test were used. Results: Forty newborns were included [14 non-HT; 26 HT with T(norm)aEEG &lt;24 h in 14/26 (group(1-HT)) and T(norm)aEEG &gt;= 24 h in 12/26 (group(2-HT))]. Severe asphyxia was present in 26/40 [5/14 non-HT, 11/14 and 10/12 in both HT groups]. PB-CL, Vd and t(1/2) were similar between the non-HT and HT group. However, within the HT group, PB-CL was significantly different between group(1-HT) and group(2-HT) (p = .043). ANOVA showed that HT (p = .034) and severity of asphyxia (p = .038) reduced PB-CL (-50%). Conclusion: The interaction of severity of asphyxia and HT is associated with a clinical relevant reduced PB-CL, suggesting the potential relevance of disease characteristics beyond HT itself.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

The Journal of Maternal-Fetal &amp; Neonatal Medicine

ISSN

1476-7058

e-ISSN

—

Svazek periodika

32

Číslo periodika v rámci svazku

14

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

2302-2309

Kód UT WoS článku

000463528600005

EID výsledku v databázi Scopus

2-s2.0-85041559803